Here, we used cryogenic electron tomography to visualize neurites in HD patient iPSC-derived neurons with varying CAG repeats, and primary cortical neurons from BACHD, deltaN17-BACHD, and wild-type mice. In HD models, we discovered sheet aggregates in double membrane-bound organelles, and ...
Mammalian neocortical neurons span one of the most diverse cell type spectra of any tissue. Cortical neurons are born during embryonic development, and their maturation extends into postnatal life. The regulatory strategies underlying progressive neurona
Effects of hypoxia, substrate deprivation and simulated ischemia (combined hypoxia and substrate deprivation) on cell survival during the insult itself and during a 24 h 'recovery' period were studied in primary cultures of mouse astrocytes and in cerebral cortical neuronal-astrocytic co-cultures. Cell...
Early cortical processing of visual information has long been investigated by describing the response properties such as receptive fields or orientation selectivity of individual neurons to moving gratings. However, thanks to recent technological advances, it has been become easier to record from larger ...
Indeed, a number of studies have shown that a damaging insult to brain tissue is able to induce the PRKCD gene in cells such as cortical neurons, astrocytes and in microglia, in which it is not present under physiological conditions [48]. A summary of the results from this study showing ...
Visual experience reduces the spatial redundancy between cortical feedback inputs and primary visual cortex neurons 2024, Neuron Citation Excerpt : While most of the GCaMP6s-expressing neurons were confined to LM, parts of adjacent area laterointermediate (LI) area were also labelled in some mice....
Understanding Layer 4 of the Cortical Circuit: A Model Based on Cat V1 This paper reviews theoretical and experimental results on the processing of layer 4, the input-recipient layer, of primary visual cortex (V1). A wide rang... Miller,D K. - 《Cerebral Cortex》 被引量: 117发表: 200...
Brain-derived neurotrophic factor (BDNF), a promoter of synaptic plasticity, significantly increased MCT2 protein expression in cultured cortical neurons (as shown by immunocytochemistry and western blot) through a translational regulation at the synaptic level. Brain-derived neurotrophic factor can cause ...
FMRP bindsMAP1BmRNA in a wide range of cell types, including neurons30,31,32. However, only limited studies have assessed MAP1B protein levels in FMRP-deficient cells8,18,19. MAP1B protein levels are elevated in the hippocampus and primary cortical neurons derived fromFmr1-KOmice19but no ...
NEURONSDEMYELINATIONSOMATOSENSORY cortexMYELIN sheathOLIGODENDROGLIANERVOUS system regenerationAxons in the cerebral cortex show a broad range of myelin coverage. Oligodendrocytes establish this pattern by selecting a cohort of axons for myelination; however, the distribution of myelin on distinct neurons and...