septic shockmouse modelsinnate immunitycytokinesAbstractAn extensive network of regulation of systemic inflammation makes development of a reproducible experimental model of sepsis a complex task. There is no single mouse model that can capture all clinical aspects of this complicated pathology. However, ...
MP Fink, SO Heard Laboratory models of sepsis and septic shock. J Surg Res, 49 (1990), pp. 186-196 View PDFView articleView in ScopusGoogle Scholar 36 Gertz SD, Fallon JT, Gallo R, et al. Hirudin reduces tissue factor expression in neointima after balloon injury in rabbit femoral and ...
In septic mice, 3-hydroxybutyrate-sodium-salt has shown to partially prevent sepsis-induced muscle weakness. Although effective, the excessive sodium load was toxic. We here investigated whether ketone ester 3-hydroxybutyl-3-hydroxybutanoate (3HHB) was a safer alternative. In a mouse model of abdom...
Intracranial injection of recombinant stromal-derived factor-1 alpha (SDF-1α) attenuates traumatic brain injury in rats Pubmed:24352531 J Clin Periodontol. Experimental peri‐implant mucositis at different implant surfaces Pubmed:24521508 Inflammation Effects of honokiol on sepsis-induced acute kidney inj...
Article https://doi.org/10.1038/s41467-023-41484-3 CREB1-driven CXCR4hi neutrophils promote skin inflammation in mouse models and human patients Received: 1 November 2022 Accepted: 6 September 2023 Check for updates Jiaoling Chen 1,4, Yaxing Bai 1,4, Ke Xue 1, Zhiguo Li 1, Zhenlai Zhu...
[82]. It is interesting that we did not observe an effect by VT on tumour growth as Ang1 has previously been reported to suppress tumour growth in some models [83–86]. In the case of tumours (such as gliomas) with Tie2-expressing parenchymal cancer cells, exogenous Ang1 treatment has...
They may include differences in either the underlying causes of atherogenesis or the mechanism(s) of lipoprotein oxidation in the different animals used in these models. Regarding the latter, most mechanistic studies addressing lipoprotein oxidation and antioxidation have used human LDL and focused on ...
an important cause of morbidity and mortality in patients with Gram-negative sepsis and endotoxemia, especially in liver transplantation recipients.1,2 It is widely accepted that the development of septic liver injury involves increa- sed susceptibility of the liver to inflammation and oxidative stress...
The importance of analyzing routine chemistries in living genetically manipulated mice is increasingly clear. Analogous data bases of serum and/or plasma analytes exist for humans, are commonly used in screening human patients for the presence of health
A wide array of murine models has been described for identifying pathophysiological and molecular mechanisms that underlie sepsis and septic shock. However, the investigator's preference for a specific type of model often remains somewhat hampered since manifold aspects of physiological and technical ...