Beal, M.F., and Ferrante, R.J., 2004, Experimental therapeutics in transgenic mouse models of Huntington’s disease. Nat. Rev. Neurosci. 5: 373–384.Beal MF, Ferrante RJ (2004) Experimental therapeutics in tran
In the brains of mice with Huntington disease (HD), the transcriptional repressor histone deacetylase 4 (HDAC4) colocalizes with mutant huntingtin to form cytoplasmic inclusions, according to research reported in PLoS Biology. Mielcarek et al. found that an HDAC4 knock-down in these animals ...
Huntington’s disease is an inherited neurodegenerative disorder for which a wide range of disease-modifying therapies are in development and the availability of biomarkers to monitor treatment response is essential for the success of clinical trials. Baseline levels of neurofilament light chain in CSF ...
Huntington's disease (HD) is a monogenetic, neurodegenerative disease. It is fatal, and although treatments are available for minor symptomatic relief, it remains incurable. Careful study of models...doi:10.1007/978-1-61779-301-1_1Miriam A. Hickey...
intrabodies that had been shown, in cell cultures and fruit-fly models, to reduce the accumulation of toxic Htt protein. To see whether those effects would hold true in mammalian systems as well, the team tested the intrabodies in a series of five different mouse models of Huntington's. ...
Mouse models of Huntington's disease Trends in Pharmacological Sciences Volume 23, Issue 1, 1 January 2002, Pages 32-39 Purchase options CorporateFor R&D professionals working in corporate organizations. Academic and personalFor academic or personal use only. CliniciansFor doctors, nurses, and other ...
Acta Neuropathologica Communications https://doi.org/10.1186/s40478-020-0878-0 (2020) 8:14 RESEARCH Open Access Thalamostriatal degeneration contributes to dystonia and cholinergic interneuron dysfunction in a mouse model of Huntington's disease Gabriel Crevier-Sorbo, Vladimir V. Rymar, Raphael ...
The R6/2 transgenic mouse model of Huntington’s disease (HD) carries several copies of exon1 of the huntingtin gene that contains a highly pathogenic
Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models. Hum Mol Genet. 2009; 18 :1006–1016. doi: 10.1093/hmg/ddn428. [ Cross Ref ]Phan J, Hickey MA, Zhang P, Chesselet MF, Reue K (2009) Adipose tissue dysfunction tracks disease progression in two...
Downregulation in the expression of genes involved in the cholesterol synthesis pathway is seen in cortical tissue of patients with Huntington's disease, and in mouse and cell models of the disease [99, 100]. Neurite outgrowth and synaptogenesis In adult mice, reduction in neural expression of ...