Hennighausen L. Mouse models for breast cancer. Breast Cancer Res 2000;2(1):2-7.Hennighausen L. Mouse models for breast cancer. Breast Cancer Res 2000; 2: 2- 7.Hennighausen L (2000) Mouse models for breast cancer. Oncogene 19 : 966–967....
A critical step towards the generation of mouse models of breast cancer is the understanding of the molecular pathways underlying mammary carcinogenesis. Our knowledge on how breast tumor progression occurs has also been markedly improved by unraveling the dynamics and the key factors of mammary gland...
Mouse Models of Breast Cancer Breast cancer is the most common cause of cancer death in women worldwide. This malignancy is a complex disease, which is defined by an intrinsic heterogen... K Sakamoto,JW Schmidt,KU Wagner - 《Methods Mol Biol》 被引量: 2发表: 2015年 Oncogenic and tumor‐...
Breast cancer is the most frequently diagnosed malignancy and results in the highest cancer mortality in women aged 20–59 years worldwide [1]. The disease usually progresses from hyperplasia to ductal carcinoma in situ (DCIS), and subsequently invasive carcinoma and metastasis, the latter ...
Mouse models of breast cancer metastasis to bone Breast cancer frequently metastasizes to bone, where it takes a significant toll on quality of life. Models of bone metastasis are needed in order to bette... KL Kretschmann,AL Welm - 《Cancer & Metastasis Review》 被引量: 0发表: 2012年 Mou...
(2013). Mouse models of BRCA1 and their application to breast cancer research. Cancer Metastasis Rev. 32, 25-37.Dine J, and Deng CX. Mouse models of BRCA1 and their application to breast cancer research. Cancer Metastasis Rev. 2013; 32: 25-37....
Breast tumor heterogeneity has been well documented through the use of multiplatform -omic studies in human tumors. However, there is no integrative database to capture the heterogeneity within mouse models of breast cancer. This project identifies genomic copy number alterations (CNAs) in 600 tumors...
Oncogene (2021) 40:475–491 https://doi.org/10.1038/s41388-020-01560-0 REVIEW ARTICLE Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo Sherif Attalla 1,2 ● Tarek Taifour 2,3 ● Tung Bui2 ● William Muller 1,2,...
A substantial part of all hereditary breast cancer cases is caused by BRCA1 germline mutations. In this review, we will discuss the insights into BRCA1 functions that we obtained from mouse models with conventional and conditional mutations in Brca1. The most advanced models closely resemble human...
In fact, the majority of extracellular proteases are provided by stromal cells rather than cancer cells. This distinct expression pattern is seen in human breast cancers and also in transgenic mouse models of breast cancer. The similar expression patterns suggest that transgenic mouse models are ...