Lau YS, Meredith GE. From drugs of abuse to parkinsonism. The MPTP mouse model of Parkinson's disease. Methods Mol Med. 2003; 79 :103–16.Lau YS, Meredith GE (2003) From drugs of abuse to parkinsonism. The MPTP mouse model of Parkinson's disease. Methods Mol Med 79: 103-16....
Hyposmia, a reduced sense of smell, affects more than 90% of all Parkinson’s disease (PD) patients, with a minority of these patients experiencing anosmia, a complete loss of their sense of smell1,2. This olfactory dysfunction can occur up to 10 years before the onset of motor symptoms ...
Anatomic and Disease Specificity of NADH CoQ1 Reductase (Complex I) Deficiency in Parkinson's Disease 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is thought to produce parkinsonism in humans and other primates through its inhibition of complex I. Th... AHV Schapira,VM Mann,JM ...
YOON, M-H.; LEE, D-W.; KIM, H-J.; CHUNG, J-Y.; DOO, A-R.; PARK, H-J.; KIM, S-N.; CHOE, B-Y. Investigation of the neuroprotective effects of bee-venom acupuncture in a mouse model of Parkinson's disease by using immunohistochemistry and In-vivo1H magnetic resonance ...
The pathological hallmark of Parkinson’s disease (PD) is the formation of Lewy bodies containing aggregated alpha-synuclein (α-syn). Although PD is associated with these distinct histological changes, other pathological features such as microvascular a
Spinelli, K.J.; Taylor, J.K.; Osterberg, V.R.; Churchill, M.J.; Pollock, E.; Moore, C.; Meshul, C.K.; Unni, V. Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease. J. Neurosci. 2014, 34, 2037-2050....
We propose that DDD mice represent a novel acute model of severe DA deficiency that might be used to identify compounds with potential therapeutic use for the treatment of Parkinson's disease (PD). This model is particularly promising as a tool for evaluating the efficacy of compounds that may...
Objectives Parkinson’s disease (PD) is a kind of common neurodegenerative disease in the world. Previous studies have proved that nervonic acid (NA), extracted from Xanthoceras sorbifolia Bunge, has the potentials of neuroprotection. However, the effect
Abnormal folding of α-synuclein (α-syn) is thought to lead to neurodegeneration and the characteristic symptoms of Lewy body disease (LBD). Since previous studies suggest that immunization might be a potential therapy for Alzheimer’s disease, we hypothesized that immunization with human (h)α-...
Parkinson’s disease (PD) affects millions of patients worldwide and is characterized by alpha-synuclein aggregation in dopamine neurons. Molecular tweezers have shown high potential as anti-aggregation agents targeting positively charged residues of pro