C57BL/6J x C3H/HeJ (B6C3) and C57BL/6J x SJL/J (B6SJL) F1 chimeras were obtained and maintained in our breeding colony. Transgenic 5XFAD mice expressing five familial AD mutations [3XAPP (Swedish K670N/M671L, Florida I716V, and London V717I), and 2XPS1 (M146L and L286V) ...
APPNLh/NLh X PS-1P264L/P264L mutant mice were generated using the Cre-lox knock-in technology.21, 22 The APP strategy introduced the Swedish FADK670N/M671L mutations and changed the mouse sequence for Aβ to be identical to the human sequence (NLh). These mice demonstrate proper cleav...
MMRRC 036778) were crossed with 5XFAD transgenic mice (RRID: MMRRC_034840-JAX; overexpressing 5 gene mutations related to Familial Alzheimer’s Disease (FAD), 3 mutations in human APP (Swedish, K670N, M671L; Florida, I716V; and London...
SUBJECTS AND METHODS Mice Tg mice express a human b APP695 transgene with both the Swedish (K670N-M671 L) and Indiana (V717F) familial AD mutations under the regulation of the Syrian hamster prion promoter (PrP) (Chishti et al, 2001) and were obtained from Dr David Westaway (...
Tg2576 mice, overexpressing the human APP double mutation K670N/M671L (isoform 695), under the control of the hamster prion protein promoter (Hsiao et al., 1996), were bred with B6/SJL F1 female mice. For all studies, both male and female mice were used and they were allocated ...