The roles of Aβ low-threshold mechanoreceptors (LTMRs) in transmitting mechanical hyperalgesia and in alleviating chronic pain have been of great interest but remain contentious. Here we utilized intersectional genetic tools, optogenetics, and high-spee
From 14–20 weeks, the P:I:C distributions did not differ significantly from “K5” (“vs. K5”) by Fisher's exact test. (H) Interpretation of observed β-gal labelling patterns. In the box and whisker plots in A, F and other figures, the whiskers show the minimum and maximum ...
The Mere Click of a Mouse Puts Readers in the PictureSTORIES about tragedy on the roads, bondage, intrigue and animal abuse were some of the most clicked items on the Daily's website this year.
cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase. We have isolated a murine cDNA encoding a ligand for the Cek5 receptor protein-tyrosine kinase (RPTK), a member of the Eph/Eck RPTK subfamily. Sequence ana... H Shao,L Lou,A Pandey,... - 《Jo...
We applied ImmuCellAI-mouse to a mouse breast tumor dataset and revealed the dynamic change of immune cell infiltration during treatment, which is consistent with the findings of the original study but with more details. We also constructed an online server for ImmuCellAI-mouse, on which users ...
OPEN Citation: Transl Psychiatry (2017) 7, e1135; doi:10.1038/tp.2017.91 www.nature.com/tp ORIGINAL ARTICLE Molecular indicators of stress-induced neuroinflammation in a mouse model simulating features of post-traumatic stress disorder S Muhie1,2, A Gautam3, N Chakraborty1, A Hoke1, J ...
Western blotting using the anti-mK6irs antibody revealed a single protein separated clearly into three isoelectric variants (Figure 5b). mK6irs ran at 57 kDa, i.e., slightly below the 58.5–59 kDa basal cell cytokeratin K5 (MK5) (Schweizer, 1993), and was located in the more basic...
However, the direct impact of high-fat diet (HFD), a cause of MASLD, on liver coagulation function is not well understood. Previously, we demonstrated that a short-term, 4-day intake of a HFD exacerbates concanavalin A (Con A)-induced acute liver injury in mice by promoting coagulation ...
as a model of distinct types of RBs in the light of cortico-dorsostriatal circuitry implication. Indeed, these new results are in line with neurophysiological modifications due to whole-striatal Sapap3 expression patterns, the clinical comorbidity observed in patients, and recent work reconsidering ...
OPEN Citation: Transl Psychiatry (2017) 7, e1013; doi:10.1038/tp.2016.290 www.nature.com/tp ORIGINAL ARTICLE Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders M Rapanelli1, L Frick1, V Pogorelov1,7, H Ohtsu2, H Bito3 ...