Background: IL-23R Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 (1‑5). The functional IL-23 receptor complex consists of two receptor subunits, the ...
IBD17; IL-23 R; IL-23 receptor; IL23R; IL-23R; interleukin 23 receptor; interleukin-23 receptor Product Datasheets Product Datasheet COA SDS Product Specific Notices This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, ...
中文名称: IL-23R, Mouse, 重组蛋白 (hFc) 英文名称: IL-23R Protein, Mouse, Recombinant (hFc) 品牌: TargetMol 产地: 美国 保存条件: Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month | Shipping with blue ice. 产品类别: 抑制剂 货号: TMPJ-01219 Pro...
IL-23R蛋白与IL12RB1形成白细胞介素23受体,是IL23的关键结合位点。IL-23R 介导 T 细胞、NK 细胞以及可能的巨噬细胞/骨髓细胞的刺激,从而激活 Jak-Stat 信号级联。IL-23R Protein, Mouse (HEK293, His) 是重组的 IL-23R 蛋白,由 HEK293 表达,带有 C-His 标签。IL-23R Protein, Mouse (HEK293, His) ...
产品名称:RecombinantMouseInterleukin-23Receptor/IL-23R说明书 KnownasInterleukin-23receptor;Il23r;IL-23receptor;IL-23R;interleukin23receptor DerivedfromHumanCells PurityGreaterthan95%asdeterminedbyreducingSDS-PAGE. FormulationLyophilizedfroma0.2μmfilteredsolutionofPBS,pH7.4. ShippingTheproductisshippedatambienttem...
白细胞介素23(IL-23)是一种由IL-12p40亚基和IL-23p19亚基组成的异二聚体细胞因子,其中p40亚基是IL-23与IL-12共用的。IL-23的功能性受体已被鉴定,由IL-12Rβ1和IL-23R组成。IL-23在1型极化T细胞的免疫应答中起作用。虽然IL-12可强有力激活幼稚T细胞,但是最初的报道认为IL-23可优先作用于记忆T细胞,促进...
ChemicalBook provide Chemical industry users with Mouse IL-23R PE-conjugated Antibody Boiling point Melting point,Mouse IL-23R PE-conjugated Antibody Density MSDS Formula Use,If You also need to Mouse IL-23R PE-conjugated Antibody Other information,welco
p19亚基:189氨基酸(19 kDa),含4个α螺旋,特异性结合IL-23R(与IL-12Rβ1无关)。 p40亚基:与IL-12共享,形成二硫键(Cys177-Cys278)稳定异源二聚体。 活性形式:IL-23(p19/p40)通过结合IL-23R/IL-12Rβ1复合物传递信号。 (2) 信号通路 Th17极化:IL-23→STAT3磷酸化→上调RORγt/IL-17A→驱动炎症反...
termed IL-23R. IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 was found not to induce significant amounts of IFN-gamma. Mouse IL-23 does induce strong proliferation of memory T c...
IL-23是另一种异二聚体细胞因子,由一个独特的 p19 亚基和 IL-12 的 p40 亚基组成,具有与IL-12相似和不同的生物活性。IL-12由巨噬细胞和B细胞产生,已被证明对T细胞和自然杀伤(NK)细胞有多种作用。IL-23由活化的树突状细胞和巨噬细胞分泌,并通过IL-23R与IL-12Rβ1复合的受体发出信号。IL-23已被证明能...