The effects of phosphorothioate antisense oligonucleotides (ASO), complementary to the AUG start region, the junctional region of the intron and exon, and to exon of the procollagen type III gene, were investigated in a mouse hepatic stellate cell (HSC) line transformed by the simian virus 40 ...
Having demonstrated the responsiveness of PRL to FAP in a cell-free setting, we next assessed PRL responsiveness to aHSC using the human LX-2 hepatic stellate cell line as a model system. In these experiments, LX-2 cells or Chang cells, used as a FAP-negative control cell, were treated w...
CD1d molecules are mainly expressed by APCs, including hepatic stellate cells (Winau et al., 2007). In addition, cortical thymocytes as well as some activated T cells express CD1d proteins (Dougan et al., 2007a). Expression of CD1d on the surface of APCs is enhanced by proinflammatory ...
The human hepatocellular cell line HepG2 and the human activated hepatic stellate cell (HSC) line LX-2 were obtained from the Japanese Collection of Research Bioresources Cell Bank (Osaka, Japan) and Merck KGaA (Darmstadt, Germany), respectively. The human intestinal epithelial cell line Caco-2...
Using DNA microarrays, we demonstrated that gene expression in TWNT-4 cells, an activated human hepatic stellate cell line, was remarkably altered by IFN-β more than by IFN-α. Integrated pathway enrichment analyses revealed that a variety of IFN-β-mediated signaling pathways are uniquely ...
Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells by suppressing gene expression of lectin-like oxidized LDL receptor-1. Type II diabetes mellitus (T2DM) is often accompanied by non-alcoholic steatohepatitis (NASH) and associated with hypercholesterolemia, that is, increased .....
METHODS: Mouse LPCs were co-cultured in Transwell plates with an immortalized human hepatic stellate cell line (HSC-Li) we previously established. The morphology, expression of hepatic markers, and functions of mouse LPC-derived cells were monitored and compared with those of conventionally cultured...
The endocannabinoid 2-arachidonoylglycer induces death of hepatic stellate cells via mitochondrial reactive oxygen species FASEB J., 21 (2007), pp. 2798-2806 CrossrefView in ScopusGoogle Scholar 39. Siegmund S.V., A. Wojtalla, M. Schlosser, A. Zimmer, M.V. Singer Fatty acid amide hydrol...
Such diversity of epithelial progenitor cell subtypes might also reflect the remarkable plasticity noted by earlier studies35,46. Aside from the discovered epithelial stem-cell types, our unbiased scRNA-seq approach uncovered different subtypes within incisor epithelium including the subtypes of stellate ...
Mouse LPCs were co-cultured in Transwell plates with an immortalized human hepatic stellate cell line (HSC-Li) we previously established. The morphology, expression of hepatic markers, and functions of mouse LPC-derived cells were monitored and compared with those of conventionally cultured LPCs. ...