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Heart (HEA), liver (LIV), spleen (SPL), kidney (KID), and testis (TES) were dissected and weighed. Tissue weight was measured and represented as a percentage of BW excluding fat and internal organs. Dorsal and inguinal deposits of subcutaneous fat tissues (SFAT), perirenal, gonadal, and...
Six GATA1 OSs that are specific to mouse generated positive enhancer assays; only one (16%) showed expression in tissues other than blood vessels and heart. By contrast, among 12 additional occupancy-conserved GATA1 OSs with in vivo enhancer activity, 6 (50%) were active in non-erythroid ...
Heart Fail Rev 23, 773–788, https://doi.org/10.1007/s10741-018-9721-0 (2018). Article CAS PubMed Google Scholar Schwinge, D. et al. Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis. ...
heart. Ven, Ventricular; OFT, Outflow tract; Epi, Epicardial.jSpatial expression of selected sub-domain specific marker genesMyl1(Atrial),Myl2(Ven),Eln(OFT), andNsrp1(Epi).kThe spatial map of predicted cell types in the heart region.lSpatial visualization of deconvoluted weights of 8 heart...
Fetal growth restriction (FGR) refers to pathologically reduced fetal growth, which occurs in about 5–10% of pregnancies worldwide1,2,3. FGR is one of the largest contributors to perinatal mortality and morbidity4,5,6,7,8,9, and predisposes individuals to heart disease, hypertension, type ...
the role of innate lymphocytes in the ovary is an unexplored subject. Type 17 γδTs play critical roles during fibrosis in a variety of organs, including liver84,85, kidney86, lung87and heart88. However, whether these cells are protective or deleterious in fibrosis appears to be dependent...
To define the contribution of this locus to DS phenotypes, we used genome editing to correct its copy number in a mouse model of DS, which normalized antiviral responses, prevented heart malformations, ameliorated developmental delays, improved cognition and attenuated craniofacial anomalies. Triplication...
45have shown that global KO ofSgpl1results in sickly mice having lymphopenia and markedly reduced lifespan. Lexicon’s comprehensive histological examination showed lung, heart and urinary tract lesions, along with osteopetrosis. Osteoclasts are plentiful but have increased cytoplasmic volume and show ...
(Grik4-cre)G32-4Stl (Grik4-cre) has been reported to be active in the CA3 region of the hippocampus by E13.5 with low cre recombination rates in other parts of the brain25. We observe hippocampal expression (Fig. 3h), as well as widespread activity in heart and lung tissue (Fig. ...