Three-dimensional (3D) genome organization allows interactions of genes with their distant cis-regulatory elements, through chromatin looping and compartmentalization, and is thought to play a major role in transcriptional regulation15,16,17. Within the brain, 3D genome remodelling has only recently ...
A recent report35 demonstrates efficient in vivo prime editing in enriched degenerating retinitis pigmentosa mouse retinas with dual-AAV delivery of PE-SpRY, but this system may not be applicable to uses that do not confer a survival advantage among edited cells. Adenoviral transduction has yielded ...
the compact version has a large introduction on stereotaxic surgery and the use of the atlas in the lab, as well as a number of panoramic simplified diagrams for student instruction. the compact 3rd edition is in 8.5 x 11 format and is spiral bound suitable for positioning next to microsc...
A robotic game of cat and mouse playing out in a lab provides a peek at future possibilities of robots carrying out search-and-rescue missions or wildlife surveys without much human guidance. The Tianjicat robot developed by researchers atTsinghua Universityin China uses a brain-inspired computing...
We suggest that micro-CT of the mouse brain could be used for neurohistological lesions evaluation as an alternative to classical neurohistology because it does not destroy brain tissue. 1. Introduction Microcomputed tomography (micro-CT) scanning provides nondestructive imaging of tissues and has ...
Topology of the mesoscale connectome of the mouse brain The wiring diagram of the mouse brain has recently been mapped at a\nmesoscopic scale in the Allen Mouse Brain Connectivity Atlas. Axonal\nprojections from brain regions were traced using green fluoresent proteins. The\nresulting data we......
The brain consists of many cell classes yet in vivo electrophysiology recordings are typically unable to identify and monitor their activity in the behaving animal. Here, we employed a systematic approach to link cellular, multi-modal in vitro properties from experiments with in vivo recorded units ...
Finally, consider need for meaning. We can either live our life such that it has a meaningful frame of reference or we can keep encountering the absurd. We all have a desire to make sense of our lives, and we can either use the narrative self to weave a story around our adventures or...
Mu-opioid receptors (MOPRs) are the target of heroin and other prescription opioids, which are currently responsible for massive addiction morbidity in the US. The gene coding for the human MOPR (OPRM1) has an important functional single nucleotide polym
During neurogenesis, mitotic progenitor cells lining the ventricles of the embryonic mouse brain undergo their final rounds of cell division, giving rise to a wide spectrum of postmitotic neurons and glia1,2. The link between developmental lineage and ce