(aa) core FGF domain that exhibits a beta -trefoil structure (1, 2). Unlike other FGF subfamilies, FGF-19 subfamily members exist as highly diffusible molecules that is attributed to poor ECM/heparin sulfate binding (3-6). The cDNA for mouse FGF-23 predicts a 251 aa polypeptide that ...
Such an ELISA profile has been interpreted to reflect increased FGF23 synthesis offset by increased FGF23 cleavage.5 This profile may also reflect local consumption of the intact hormone in the BM. Indeed, Ishii et al64 found that after G-CSF treatment, both iFGF23 and cFGF23 levels were ...
Forty-eight cytokines including FGF basic, Eotaxin (also known as CCL11), G-CSF (CSF3), GMCSF (CSF2), IFN-γ, IL-1β, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8 (also known as CXCL8), IL-9, IL-10, IL-12 (p70), IL-13, IL-15, IL-17α, IP10 (CXCL10), ...
N/A View Larger Detection of Selected Mouse Cytokines in CMT-93 Cell Line Lysate.Lysates from CMT-93 mouse rectal carcinoma cells were untreated or treated with 100 ng/mL LPS for 24 hours (200 µg lysate, 10 minute exposure). N/A ...
N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion (3). Research studies have shown that in endothelial cells, VE-cadherin signaling, expression, and localization correlate with vascular permeability and tumor angiog...
histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes (Calcr,Cebpb,Crtap,Dcstamp,Dkk1,Duoxa2,Enpp1,Fgf23,Kiss1/Kiss1r,Kl (Klotho),Lrp5,Mstn,...
Forty-eight cytokines including FGF basic, Eotaxin (also known as CCL11), G-CSF (CSF3), GMCSF (CSF2), IFN-γ, IL-1β, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8 (also known as CXCL8), IL-9, IL-10, IL-12 (p70), IL-13, IL-15, IL-17α, IP10 (CXCL10), ...
FGF2 | FIGF | FLT1 | FLT3LG | FLT4 | FRZB | GAS1 | GAS6 | GPNMB | GREM1 | GRN | GZMB | H60A | HAVCR1 | HGF | ICAM1 | IFNA11 | IFNG | IFNGR1 | IFNL2 | IGDCC4 | IGF1 | IGFBP2 | IGFBP3 | IGFBP5 | IGFBP6 | IL10 | IL12A | IL12B | IL13 | IL15 | IL17A ...
histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes (Calcr,Cebpb,Crtap,Dcstamp,Dkk1,Duoxa2,Enpp1,Fgf23,Kiss1/Kiss1r,Kl (Klotho),Lrp5,Mstn,...
DMP-1 mutations in humans are associated with hypophosphatemia and FGF-23 over-expression (11, 12). DMP-1 induces the activation of pro-MMP-9 and displaces mature MMP-9 from TIMP1 (13). DMP-1 tethers MMP-9 to the cell surface via CD44 and integrins alpha V beta 3 and alpha V ...