IM1 cells also displayed elevated expression levels of MIF and CD44, which were predicted to interact with EGF receptor (EGFR) and proheparin-binding EGF-like growth factor (HBEGF) receptors of cells assigned to the Beta2/3 cluster (beta cells enriched in NZO +CH-fed mice) (Fig.7a). Th...
principles of scientific consistency and reproducibility71. At all sites, phenotype assessment and interpretation were made by specialized personnel with expertise in a variety of fields, including pathologists, veterinarians, radiologists, ophthalmologists, cardiologists, and scientific experts in neurobehavior...
resulting in their expansion and altered hematopoiesis, a result that brings into question the widespread use of CD4-Cre as driver of T-cell-specific gene deletion and suggests a cautious interpretation of studies with this Cre driver, especially in contexts where deletion results in loss of expres...
Following positive results from transient transfection of the hTNF.LucBAC construct into the neuroblastoma and colon carcinoma cell-lines, we sought to establish a robust, stably integrated system. Linearised hTNF.LucBAC DNA was pronuclear-injected into C57/BL6J mouse embryos and established a mous...
Targeting EGF-receptor-signalling in squamous cell carcinomas of the head and neck Br. J. Cancer, 96 (2007), pp. 408-416, 10.1038/sj.bjc.6603566 Google Scholar [29] M. Hanawa, S. Suzuki, Y. Dobashi, T. Yamane, K. Kono, N. Enomoto, et al. EGFR protein overexpression and gene am...
There is a significant depletion of EGF in affected submandibular salivary glands during the convalescent stages of the disease. Active infection has been reported to precipitate graft-versus-host disease in the salivary and lacrimal glands of rats with allogenic bone marrow grafts. Noninfectious ...
Figure 8 showed that Agt directly inhibits the expression of Lep, Hmgcr, and Ldlr and Egf negatively regulates the expression of Lep. Conversely, Lep and Hmgcr could regulate the expression of Ccl12. The results show that HS intake reduces fat deposition in mouse adipose tissue through RAS ...
Prolonged inflammation results in increased fibroblast (FB) activity, with enhanced secretion of transforming growth factor beta 1 (TGFβ1), TGFβ2, insulin-like growth factor (IGF1), and other cytokines6. TGFβ1 drives dif- ferentiation of FBs into myofibroblasts, which have a contractile ...
Although the results for both PMMA and HDPE were not statistically significant, a dose-dependent trend was observed, prompting their inclusion in the interpretation of the results. PMMA induced increases of 0.8-, 1.3-, 2.0-, and 1.7-fold at concentrations of 6.25, 12.5, 25, and 50 µg·...
Taken together, these results showed that HSHH reduced asthmatic parameters in a mouse model of allergic asthma, and suggest that SHH could be used as a potential therapeutic agent for asthma. Keywords: airway smooth muscle cell; asthma; cytokines; sea hare hydrolysates 1. Introduction Sea hare,...