Inbred lab mice are not isogenic: genetic variation within inbred strains used to infer the mutation rate per nucleotide site ArticleOpen access31 August 2020 Main Inbred laboratory strains of mice are broadly organized into two groups, classical and wild-derived strains1, that can be used to mod...
Mouse inter-subspecific consomic strains for genetic dissection of quantitative complex traits.Consomic strains, also known as chromosome substitution strains, are powerful tools for assigning polygenes that control quantitative complex traits to specific chromosomes. Here, we report generation of a full ...
diabetes and mouse NOD β-cells. We also report pathways that are shared between β-cells in immature, aged and diabetes models. MIA enables a comprehensive analysis of β-cell responses to different stressors, providing a roadmap for the understanding of β-cell plasticity, compensation and dem...
The ciliary proteome database: an integrated community resource for the genetic and functional dissection of cilia Nat. Genet., 38 (2006), pp. 961-962 CrossrefView in ScopusGoogle Scholar 17 Inglis P.N., Boroevich K.A., Leroux M.R. Piecing together a ciliome Trends Genet., 22 (2006)...
be regulated by steroid hormones that respond to morphine, heroin and ethanol. This is in agreement with activation of the hypothalamic-pituitary-adrenal axis (HPA) after administration of opioids and ethanol [74,75]. Our pharmacological dissection of drug-regulated gene expression profiles showed ...
Thus, in addition to the dissection of motion circuits, this task also allows for the study of the neural mechanisms of temporal integration in decision making in a head-fixed mouse preparation [52]. In summary, the head-fixed motion task we describe here reveals a role for visual cortex ...
Insert the tips of sterile scissors into the incision site and gently spread to the adjacent region, developing a dissection plane between the nearby skin and the tumor. Extend the incision to expose the tumor (if needed), and resect the tumor from the adherent deep tissue....
E14.5–E15.5 and E18.5. Viability at a given stage is assessed by scoring homozygous embryos for the presence of a heartbeat at dissection, as described in Dickinson et al.21. To establish windows of lethality, we considered a gene lethal at a given stage if no live homozygous embryos wer...
J. Murine hind limb long bone dissection and bone marrow isolation. JoVE https://doi.org/10.3791/53936 (2016). Kwok, I. et al. Combinatorial single-cell analyses of granulocyte-monocyte progenitor heterogeneity reveals an early uni-potent neutrophil progenitor. Immunity 53, 303–318 (2020). ...
Rosen MB, Lee JS, Ren H, Vallanat B, Liu J, Waalkes MP, Abbott BD, Lau C, Corton JC: Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR. Toxicol Sci. 2008, 103 (1): 46-56. 10....