The levels of serum ALT, AST, liver IL-6, TNF-α, and IL-1β mRNA and liver pathological injury scores were further increased when pretreated with recombinant IL-27 in WT mice, but these levels were decreased in IL-27r−/− mice after CLP-induced severe infection compared to WT mice...
This work provides the first description of the mouse CLP as the precursor of all lymphoid populations. Article CAS PubMed Google Scholar Iwasaki, H. & Akashi, K. Myeloid lineage commitment from the hematopoietic stem cell. Immunity 26, 726–740 (2007). Article CAS PubMed Google Scholar ...
Lewy bodies are considered the prime histological marker for PD. The design of isoform-selective PLK2 inhibitors is essential for targeting CNS diseases to avoid the potential toxicity associated with PLK1 inhibition in dividing cells. Because of the high homology of PLK isoforms, developing an ...
Flow cytometry analysis revealed that loss of Hes1 resulted in increased CMP at the expense of CLP in Hes1fl/flFlt3Cre fetal liver (Fig. 2B). Among the myeloid progenitors, we found that the frequencies of CMP and GMP were significantly higher, whereas MEP frequency was notably lower in ...
In vivo, we observed that treatment with rEgAgB significantly increased the survival rate of mice with CLP-induced sepsis up to 72 h while all mice without treatment died within the same period. The increased survival was associated with reduced pathological damage in key organs such as liver, ...
Six dysregulated miRNAs in both the CP and CLP plasma samples were validated by qRT-PCR: miR-340–5p, miR-877–5p, miR-3648, miR-1260a, miR-494–3p, and miR-1304–3p. While the potential targets for these miRNAs remain unidentified, all 212 dysregulated miRNAs targeted genes that were ...
± 20 cells/mm(2); P < 0.05) in cerebral microcirculation, EB leakage (WT-CLP:10 ± 3.7; Adko-CLP:24 ± 4.3 ng/g × l plasma; P < 0.05) and E-selectin expression (WT-CLP:0.06 ± 0.11; Adko-CLP:0.44 ± 0.053 ng/g; P < 0.05) in the brain tissue of the mice with CLP....
in the cell lineages using the online bioinformatics tool DAVID in differentially spliced genes (FDR < 0.1). Total enrichment score of the GO pathways as contributed by the different alternative splicing events in plotted forbMaSC,cLP, anddLM in the comparison between EP-treated mice and sham ...
In addition to persistent neuroimmunological changes, there have been a number of studies examining cognitive and affective parameters following recovery from both LPS-induced, and cecal ligation and puncture (CLP)-induced sepsis. There is considerable variance in the behavioural changes present in post...
This demonstrates that Mx1-labeled cells are a nonspecific marker for mesenchymal progenitors cells. Mx1-expressing cells (GFP+) are identified within the CD45+, Tie2+, and [AlphaV+] subsets. 12.6% of the cells of the “Thy-6C3-“ (i.e., [CD45−Ter-119−Tie2−AlphaV+Thy−...