We, therefore, removed the cluster of vascular cells from all datasets and kept a final of 62,388 single-cell profiles with a mean of 5,444 transcripts and 2,255 genes detected per cell (Supplementary Fig. 1g–l). We performed subclustering for each major cell type from all brain ...
Recent studies have demonstrated that oligomeric Aβ induces cell senescence in cultured RPE cells by upregulating the expression of a set of senescence genes (Do et al., 2019). Our results also reflect photoreceptor senescence accompanied by Aβ deposits, characterized by increased expression of ...
Development and degeneration of retina in rds mutant mice: the electroretinogram Neurosci. Lett. (1984) S. Russell et al. Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 ...
in the genome [122]. Themdaclocus has been mapped to a 9.4 Mb region between markers D13Mit310 and D13Mit113 on chromosome 13 [122,124]. Interestingly, this region includes a cluster of KRAB-ZFP (zinc finger protein) transcription factor genes. KRAB-ZFP genes are found in multiple ...
Selective expression of intracisternal A-particle genes in established mouse plasmacytomas. Mol Cell Biol. 1993;13(12):7439–46. 83. Frankel WN, Mahaffey CL, McGarr TC, Beyer BJ, Letts VA. Unraveling genetic modifiers in the gria4 mouse model of absence epilepsy. PLoS Genet. 2014; 10(7...
To further evaluate the capacity of TRPM7 to mediate Ca2+ influx biocinneyocncoartyoerttaacresatysientosresnesiisenaopndnfotudNndcdeeeacgedltrdgrebsiatyb,osweNeaneianwalttenibrdsidatbeesteedrhnlaietnnwhrgeeeee[rs[CepoCfoaca2Nan2+u+sa]es]ileit(srdrFeiebiebsgmepy.n o4sCnactasool2een+fsbc...
The single photoreceptor sensory cilium (PSC) or outer segment elaborated by each rod and cone photoreceptor cell of the retina is a classic example. Mutations in genes that encode cilia components are common causes of disease, including retinal degenerations. The protein components of mammalian ...
19,20,21. VCAM1 is a transmembrane glycoprotein predominantly expressed in endothelial cells of tissues such as lymph nodes and bone marrow, where it plays important roles in regulating leukocyte homing via its adhesion function22. VCAM1 is one of the genes expressed in ALCs but not in FLCs...
namely a downregulation in visual perception pathways and an upregulation in inflammation and immune system response genes, as would be expected if the photoreceptors were starting to die at this age, we were surprised to detect a unique conspicuous feature of theAdipoR1KO at two weeks of age ...
Cell-type distributions were inferred through integration with a scRNA-seq dataset published by Habermann et al.5(2020;GSE135893).c, Summarizing descriptions of the data, including the number of Visium capture spots per sample and the average number of unique genes detected per spot and sample. ...