Entrez Gene IDs 3815 (Human); 16590 (Mouse); 64030 (Rat) Alternate Names CD117 antigen; CD117; ckit; c-kit; EC 2.7.10; EC 2.7.10.1; KIT; PBT; piebald trait; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCF R; SCFR; SCFRmast/stem cell growth factor receptor...
Importantly, we recently showed that about 20% of SCID-Rasa3−/− mice developed a preleukemia consisting in a massive infiltration of bone marrow and spleen with CD117+ Sca-1+ CD38+ cells, probably leading to bone marrow failure and premature death in these mice (Molina-Ortiz et al.,...
Mouse splenocytes gated on hematopoietic lineage negative cells were stained with Rat Anti-Mouse CD117/c-kit APC-conjugated Monoclonal Antibody (Catalog # FAB1356A) and either (A) Rat Anti-Mouse Sca-1/Ly6 PE-conjugated Monoclonal Antibody (Catalog # FAB1226P) or (B) Rat IgG2APhycoerythrin...
12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. Background: Osteopontin/OPN
Human cells were stained using antibodies specific for (clone names given in parentheses) the following: CD10 (HI10A), CD11c (3.9), CD16 (3G8), CD45 (HI30), CD117 (A3C6E2), CD203 (NP4D6), CD235 (HIR2), IgM (MHM-88), and NKp46 (9E2) (all BioLegend); CD2 (RPA-2.10),...
Delta-like protein 1 (DLL1) is a 90-100 kDa type I transmembrane protein in the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. Mature rat DLL1 consists of a 520 amino acid (aa) extracellular domain (ECD) with one DSL domain and eight EGF-like repeats, a 23 aa transmembrane se...
(blood, spleen, bone marrow). We also noted an increased proportion of human CD1c+cells in spleen of infected NSG-cmah−/−mice compared to wt NSG. Corresponding increasesin myeloblasts (CD34+CD117+), promonocytes (CD4dimCD14neg or dim), and mature monocytes (CD4dimCD14bright) in ...
Background: CD69 CD69, also known as Leu 23, AIM, EA-1 and MLR-3, is a type II transmembrane glycoprotein and is expressed on activated T cells, B cells, NK cells, neutrophils and eosinophils, Langerhans cells and platelets. The C-terminal extracellular domain of mouse CD69 shares appro...
(residues 20 to 318) was expressed in the NS0 cells with a foreign signal peptide. After being treated with thermolysin, the purified enzyme is active against a peptide substrate described in the Activity Assay Protocol. Apparently, the human gene corresponding to Prss34 encodes a protein that ...
Encoded by the THBD gene, Thrombomodulin is also known as CD141 antigen. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a mature chain (aa 17 to 577) that consists of the following domains: C-type lectin (aa 31 to 167), EGF-like (aa 240...