To address these gaps in knowledge, we perform an integrative analysis of resting and inflamed leukocytes from humans and mice and assess the degree of conservation of gene expression. We find that human and mouse transcriptomes can be analyzed together and that lineage-specific gene expression was ...
Joint mouse-human phenome-wide association to test gene function and disease risk. Nat. Commun. 7, 10464 (2016). This is the first report of PheWAS applied to the mouse BXD genetic reference panel. CAS PubMed PubMed Central Google Scholar ...
Age-associated changes in the blood brain barrier : Comparative studies in human and mouse Journal Item Age-associated changes in the blood brain barrier: Comparative studies in human and mouse Journal Item How to cite: Goodall, Emily F.; Wang, Chunfang; Simp... E Goodall,C Wang,J Simpson...
At the webinar, Ackert-Bicknell provided evidence showing that mouse genetics can inform human genome-wide association studies (GWASs) in important and interesting ways. Charles Farber and Fernando Rivadeneira also participated in a panel discussion moderated by David Karasik following Ackert-Bicknell's...
(OR, 5.59; 95% CI, 3.46-9.04; P < .001), exposure to high levels of endotoxin at age 2 to 3 months (fourth quartile compared with first quartile: OR, 2.32; 95% CI, 1.19-4.54; P = .01), and exposure to cockroach allergen of 0.05 U/g of dust or more at age 2 to 3 ...
were irradiated totally with 1 to 10 krads ~(60)Co γ-rays.Both the length and mucosal areas of small intestine were reduced predominently at 72 hours after irradiation by various doses and were of great statistical significance (P0.001) when compared with those of unirradiated control mice....
We thus identify three age-dependent phenotypic windows in the mouse model, which recapitulate the pattern seen in humans with PRRT2-related diseases.Similar content being viewed by others Mutations in the Drosophila homolog of human PLA2G6 give rise to age-dependent loss of psychomotor activity ...
- 《Human Reproduction》 被引量: 39发表: 1995年 Studies of the Growth in Culture of Excised Wheat Roots Aeration of root culture medium with air containing 5 % or 10 % CO 2 enhances growth, particularly lateral initiation and growth, compared with aeration w... B Talbot,HE Street - 《...
In the case of human trophoblasts, we have demonstrated that VEGF receptors, particularly VEGF R2, are abun- dantly expressed on first trimester trophoblasts compared to third trimester trophoblasts33. Significantly, VEGF R2, which mediates intracellular signaling, was found to be down-regulated by...
Human variable region genes from intestinal plasma cells have on average ~15 mutations.54,61 This may reflect different properties or dynamics of the GALT germinal-center response in mice, or it may reflect a more com- plex origin of murine compared with human IgA plasma cells, with ...