Summary Motor neurone disease (MND) is a progressive, neurodegenerative disorder of upper and lower motor neurones. In up to 10% of cases it is inherited, but the cause of sporadic MND is unknown. Glutamatergic excitotoxic and free radical mechanisms are thought to be important in its ...
In this Review, we use a layer-specific and cell-specific approach to integrate physiological accounts of this motor cortex microcircuit with the pathophysiology of neurodegenerative diseases affecting motor functions. In doing so we can begin to link motor microcircuit pathology to specific disease ...
A. Evidence for bilateral innervation of certain homologous motoneurone pools in man. J. Physiol. 475, 217–227 (1994). Article CAS PubMed PubMed Central Google Scholar Rossi, E., Mitnitski, A. & Feldman, A. G. Sequential control signals determine arm and trunk contributions to hand ...
McDermott CJ, Shaw PJ: Diagnosis and management of motor neurone disease. BMJ. 2008, 336: 658-662. 10.1136/bmj.39493.511759.BE. Article PubMed Central PubMed Google Scholar Orrell RW: GPs have key role in managing motor neurone disease. Practitioner. 2011, 255: 19-22. PubMed Google Scho...
Define motor endplate. motor endplate synonyms, motor endplate pronunciation, motor endplate translation, English dictionary definition of motor endplate. Noun 1. myoneural junction - the junction between a nerve fiber and the muscle it supplies neuromus
Virgo L, de Belleroche J, Ross, M and Steiner TJ (1992) Characterisation of the distribution of choline acetyltransferase messenger RNA in human spinal cord and its depletion in motor neurone disease: submitted.Virgo L. , De Belleroche J. , Rossi M. and Steiner T. J. ( 1992 ) ...
a. berardelli et al. electrical and magnetic transcranial stimulation in patients with corticospinal damage due to stroke or motor neurone disease electroencephalogr clin neurophysiol (1991) v. di lazzaro et al. comparison of descending volleys evoked by transcranial magnetic and electric stimulation ...
human ALS and in mouse models, that motor neurone death occurs by the type of 'dying back' axonal degenerative pathophysiology, that would be predicted in this model, with defects of neuromuscular transmission, end-plate denervation, and 'peripheral pruning' of axons as the earliest observed ...
Upper Motor Neurone Syndrome and Spasticity: Neurophysiology of spasticity The pathophysiology of spasticity is a complex subject and one frequently avoided by clinicians. Spasticity and the other features, positive and negative, of the upper motor neurone (UMN) syndrome arise from disruption of certain...
14. However, there are distinct species-specific microglial properties that differ between rodents and humans15and many microglial neurodegenerative disease-associated genes do not have appropriate orthologs in mouse16. The specific role of microglia in ALS pathophysiology is thus unresolved, and there ...