We aimed to transplant iPSC-derived motor neuron progenitor cells (iMNP) as a second combination cell source to increase the motor neuron differentiation rate at the lesion site in a chronic SCI model. Trials of ideal cell types and cell transplantation strategies for chronic SCI are required to...
Since the establishment of heteronymous PA input from functionally synergistic muscles to limb motor neuron pools during development is activity dependent (Mendelsohn et al., 2015), increased PA input to Sol motor neurons after injury may be derived from heteronymous PAs. We retrogradely labeled Sol...
The establishment of functional neuromuscular circuits relies on precise connections between developing motor axons and target muscles. Motor neurons ...
These principal classes are heterogenous, and contain a diversity of neuron types, but it has been difficult to capture the importance of this diversity at the functional level. In this study, we used scRNA-seq in adult zebrafish to link the molecular diversity of MNs and V2a INs with the ...
Bottom: double-labeled image of nNOS and mRuby2 in boxed region of the upper image. Scale bar, 200 μm. n = 34 animals. c ChAT+ neuron number in the cPPN of runners and non-running controls that were injected with AAV-DIO- mRuby2 or AAV-DIO-ChAT. n = 5 animals per ...
As mentioned above, our research results did indicate that SXNI has an advantage in saving hippocampal neuron apoptosis and can induce more BDNF in hippocampal CA3 of CIRI mice to stimulate the cascade response and improve the learning and memory ability. Previous studies on hippocampal neuron loss...
A motor unit (MU) is formed by a single alpha motor neuron (MN) and the muscle fibers it innervates. The MU is essential for all voluntary movements. Functional deficits in the MU result in neuromuscular disorders (NMDs). The pathological mechanisms underlying most NMDs remain poorly understood...
numerous hNUMA+ cells which migrated out of the graft in distances ranging between 2 to 3 mm were also seen. Using human-specific antibodies against Neuron Specific Enolase and synaptophysin (markers of mature neurons), we have also shown that a majority of grafted cells developed into a neuro...
we generated single chimeric microtubules composed of differentially labeled tyrosinated and detyrosinated sections of lattice29(Fig.3F). Using this system, we could observe how individual KIF13B motors behaved as they traversed from one type of lattice onto the other. The majority of motors did...
g Overlay of AP trains elicited by a 1 s 500 pA current injection in a RAPN and in a neuron outside RA at 24 °C. h The first three APs from the AP trains shown in (g). i Average elicited spikes/s as a function of current injected (two-way ANOVA with Tukey’s post ...