Master Duel are overpowered monsters that can shut down opponents' cards and combinations. Thankfully, there are counters to the worst ones. Witch's Strike can clear an opponent's entire field and hand if they negate an effect or summon, and while it won't protect against everything, it's...
However, there is also one last win condition known as Deck out which is arguably the rarest win condition of all. If a duelist runs out of cards in their deck and thus can't draw then they will lose the game. This almost never happens in the Yu-Gi-Oh! anime, but it did occur ...