Behavioral studies on rats usually concentrate on a single trait without considering how different behaviors are linked to each other and whether there are differences in this respect between rat strains or sexes. This study aims to describe the personality structure of the Norway rat, and ...
Wiszniewski W, Lewis RA, Stockton DW, Peng J, Mardon G, Chen R, Lupski JR. Potential involvement of more than one locus in trait manifestation for individuals with Leber congenital amaurosis. Hum Genet. 2011;129(3):319-27.Wiszniewski, W., Lewis, R.A., Stockton, D.W., Peng, J....
Do women have more genes than men? Do female and male autosomal chromosomes have the same alleles? Do men have more phenotypic variation? Are autosomal genes on the same chromosome? Does X-DNA affect autosomal inheritance? Are autosomal dominant traits less common than x-linked?
Simulation of P-values for association tests when major and minor alleles are risk alleles An SNV with a low MAF is likely to have a lower chance of being discovered than a more common SNV. Even when discovered, the former has a lower chance to be included in SNV platforms than the latt...
Of these three, only TERT is recorded as a known cancer gene in the CGC database. Moreover, the 93 PID-N genes are more strongly enriched (p = 5.3 × 10−11; Fisher’s exact test) for COSMIC CGC genes than the 93 genes with the smallest non-coding driver p-values of...
trait or disease. In most cases, these were not the genes nearest to the top SNPs. “If you need to decide which associations to focus on in laboratory experiments, this approach would be a way to get a shortlist, rather than just going for the closest gene,” says Visscher. In a ...
Twenty-nine losses and 1 gain were smaller than 50 kb, which counts for 16.8% (30/179) of the detected PCNVs. Among the 1089 patients with molecular diagnoses, 23 unrelated patients had diagnoses consisting of both SNVs and CNVs including 19 patients with multiple diagnoses and 4 patients...
Based on the relatively lower ORs, we hypothesized that LN-ESRD and hypertension-attributed ESRD would more likely reveal second hits, because effects of the APOL1 genotype were less strong than in FSGS and HIVAN. The dominating effect of the APOL1 G1 and G2 renal-risk alleles may mask or...
First, we consider there is a lack of evidence that rice was domesticated in two different geographic regions, South Asia and East Asia. Secondly, we consider it unlikely that rice was domesticated twice prior to the spread of the principal allele for non-shattering in rice. Thirty years ago...
We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with ...