The variable regions of the MOPC-21 antibody share the sequences with the antibodies against all members of the dengue virus complex, and the Epstein-Barr virus gp350 protein. The recombinant MOPC-21 IgG1 kappa isotype control and mutants (natural and engineered mIgG1 isotype controls)(重组...
We also demonstrate that the rearranged c- mos sequence is maintained in three different hybridomas derived by fusion of this cell line with normal murine spleen lymphocytes, suggesting that it may play a role in the continuous growth and/or constitutive immunoglobulin production by these hybridomas...
The major κ nuclear RNA intermediate at 4.8 × 10 3 bases appears to contain the intervening sequence separating the variable (V) and constant (C) regions in the active MOPC 21 κ gene. This 4.8 × 10 3 base species is shown directly to give rise to κ mRNA. Accordingly, we propose ...