We found that the expansion of MDSC, specifically associated with the monocytic MDSC (M-MDSC): CD11b+Gr-1intLy6G-Ly6Chigh in the liver of B6 mice fed a high-fat diet contributes to liver inflammation and tolerance. M-MDSCs ... Q Xie,J Zhang,SS Ghare,... - 《Journal of Immunology》...
Monocytic MDSCs were decreased in response to treatment only in patients with clinical benefit; additionally, patients with a lower frequency of these cells after the first ipilimumab infusion experienced increased overall survival. CD8 effector memory T cell frequencies at the end of treatment were ...
The frequencies of regulatory T cells (Tregs), monocytic-myeloid-derived suppressor cells (M-MDSCs), and granulocytic-myeloid-derived suppressor cells (G-... HS Hwang,AR Han,YL Ji,... - 《Immunological Investigations A Journal of Molecular & Cellular Immunology》 被引量: 0发表: 2019年 Abnor...
Host defences play a key role in tumour growth. Some of the benefits of chemotherapy may occur through modulation of these defences. The aim of this study was to define the status of regulatory cells in women with large and locally advanced breast cancer
m Helena,Janols Helena,Wullt Marlene,Bredberg Anders,Rydén Lisa,Leandersson Karin,Lafrenie Robert M 展开 摘要: Myeloid-derived suppressor cells (MDSCs) are highly immunosuppressive myeloid cells, which increase in cancer patients. The molecular mechanism behind their generation and function is ...
A Maeda,H Eguchi,K Nakahata,PC Lo,K Yamanaka,T Kawamura,R Matsuura,R Sakai,M Asada,H Okuyama 展开 摘要: •MDSCs suppress the xenocytotoxicity by macrophages.•MDSC-induced suppression of cytotoxicity is contact dependent and IDO dependent.•MDSCs suppress NO production by macrophages....
Background: Myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) are attractive immune cells to induce immune tolerance. To explore a st... Fujimoto, KeiichiUchida, KoichiroYin, EnzhiZhu, JunKojima, YukoUchiyama, MasateruYamamoto, YasutoBashuda, HisashiMatsumoto, RyuTokushige, ...
MEK inhibition by trametinib impairs the mobilization of monocytic MDSCs to facilitate anti-tumor T cell immunity 来自 Semantic Scholar 喜欢 0 阅读量: 4 作者: M Allegrezza,N Svoronos,A Perales-Puchalt,KK Payne,J Nguyen,JR Conejo-Garcia 展开 摘要: The MEK inhibitor trametinib is ...
Myeloid-derived suppressor cells (MDSC) include immature monocytic (M-MDSC) and granulocytic (PMN-MDSC) cells that share the ability to suppress adaptive immunity and hinder the effectiveness of anti-cancer treatments. Of note, in response to interferon-γ (IFNγ) M-MDSC release the tumor-promot...