Luciferase activity relative to control were shown (n=3). Data are represented as mean ± S.E.M. P values in i and l were determined by 2-way ANOVA. P value in j was determined by one-way ANOVA. P value in k was determined by unpaired Student’s t-test. CRC: colorectal ...
Therefore, monocytes in cord blood (CB) and granulocyte colony-stimulating factor–mobilized apheresis products (G-AP), two stem cell grafts associated with reduction of acute and chronic GVHD and relative reduction of acute GVHD, respectively, were compared phenotypically and functionally. Materials ...
patients, respectively (right panel). Positivet-values (red) indicate significantly lower uptake in the large Aβ Agg [+] MCI group. Statistical cortical maps were familywise error rate corrected (α = 0.05) using cluster-extent-based thresholding with a primary cluster-defining threshold ofp...
ME microenvironmentbUMAP of the overall scRNA-seq dataset (n = 80,789 cells) after removal of patient effects. Numbers denote clusters, while colors distinguish cell types.cRelative abundances of inferred cell types in each cluster. The annotation to the right indicates the final cell type ...
TFBM frequencies were assessed by using three parametric varia- tions in the size of proximal promoter sequence scanned ((−300 bp, +0 bp) relative to the RefSeq transcription start site, (−600, +0), and (−1,000, +200)) and three parametric variations in the TFBM detection ...
The balance between cell apoptosis and survival is dependent upon the relative expression of specific genes whose products interact to determine the final outcome of apoptotic signals. Among a series of cellular events, the activation of caspases seems to be a major factor for the execution of apop...
PC12 cells express very high levels of TH (<10 ng TH/mg total protein) relative to human macrophages (~300 pg TH/mg total protein) and primary murine dopamine neurons (~700 pg TH/mg total protein). b TH values are plotted on a representative standard curve for visual comparison,...
c Histogram showed the relative expression of DEGs among all monocyte subpopulations. d Volcano plot compared upregulation of DEGs regarding mM03 vs. mM06. e Heatmaps displayed relative enrichment of each monocyte subcluster during the course of sepsis. f Curve plots showed proportion of mM03 (...
Abstract The peripheral immune system is important in neurodegenerative diseases, both in protecting and inflaming the brain, but the underlying mechanisms remain elusive. Alzheimer’s Disease is commonly preceded by a prodromal period. Here, we report the presence of large Aβ aggregates in plasma...
Differential expression inMAPTvariant carriers by cell cluster.AClusters are grouped by cell type and ranked by the number of DEGs withpFDR < 0.05 and absolute LFC > 0.2. Differential expression was determined inMAPTvariant carriers relative to non-carrier controls while covarying for age...