During tumour progression, monocytes in blood, as well as macrophages in the tumour bed, are exposed to EVs released by nearby cells [11, 12] to body fluids [13, 14]. EVs are defined as membrane fragments of various shapes released by cells during their lifespan. Using the size and ...
Furthermore, type-I IFN release is typically accompanied by inflammatory chemokines which also have have many essential and non-redundant roles in the anti-viral defence. Of particular importance is the C-X-C motif chemokine 10 (CXCL10), which has been shown to induce chemotaxis of macrophages...
Acute radiation syndrome (ARS) is caused by acute exposure to ionizing radiation that damages multiple organ systems but especially the bone marrow (BM). We have previously shown that human macrophages educated with exosomes from human BM-derived mesench
Treatment of human long-term bone marrow cultures (LTBMCs) with CCL18 resulted in significant stimulation of hematopoiesis, as measured by the total number of hematopoietic cells and their committed progenitors produced in culture. Monocytes/macrophages, whose survival was almost doubled in the ...
In pregnancy, human amniotic fluid extracellular vesicles (HAF-EVs) exert anti-inflammatory effects on T cells and on monocytes, supporting their immunoregulatory roles. The specific mechanisms are still not completely defined. The aim of this study was to investigate the ability of HAF-EVs, isolate...