autophagy could be involved in monocyte differentiation; however, although autophagy has been shown to be important for the maintenance and differentiation of the hematopoietic stem cells from which they are derived, there have been no reports on the role of autophagy during monocyte-macrophage ...
The meaning of MONOCYTE is a large white blood cell with finely granulated chromatin dispersed throughout the nucleus that is formed in the bone marrow, enters the blood, and migrates into the connective tissue where it differentiates into a macrophage.
To elucidate functional changes in the monocyte-macrophage as a consequence of differentiation and viral infection we used pulsed stable isotope labeling of amino acids in cell culture (pSILAC). This unbiased proteomics approach identified significant increased rates of synthesis of proteins involved in ...
Assays of K562 and macrophage cell supernatants confirmed that the ferric reductase activity was not due to a secreted factor. Assay of ferric reductase in normalized-iron and iron-enriched (100 microM ferric citrate) conditions showed no significant difference between Cys282Tyr (Cys282-->Tyr) ...
we have used TCRβ RNA to determine whether T cells were present in the macaque macrophage-QVOA14,15. To determine whether TCRβ RNA is also appropriate for the human MDM-QVOA, we assessed both TCRβ and CD3ε8RNA in purified T cells and quantitated their expression levels. We determined...
A hallmark of inflammatory diseases is the excessive recruitment and influx of monocytes to sites of tissue damage and their ensuing differentiation into macrophages. Numerous stimuli are known to induce transcriptional changes associated with macrophage
These data indicate a dichotomous nature of LF binding on monocyte/macrophage-differentiated HL-60 cells--one being mediated by specific LF receptors whereas the other is apparently mainly via LPS receptors after formation of an LF-LPS complex. These interactions, for which a model is proposed, ...
(1998) Difference in the blood monocyte phenotype between uremic patients and healthy controls: its relation to monocyte differentiation into macrophage in the... A Brauner,L Ying,G Halldén,... - 《Inflammation》 被引量: 64发表: 1998年 ...
Monocytesare circulatory precursors to macrophage populations, originating either from the yolk sac or the fetal liver[8]. These cells arise from myeloid progenitors, such as common monocyte progenitors (cMoP) or monocyte and dendritic progenitors (MDP)[9,10]. Beyond their involvement in phagocytic ...
Speculation The human blood-derived macrophage system should be a useful one for the investigation of enzyme replacement and other modes of therapy for the lysosomal storage diseases. During the last several years, inherited lysosomal storage dis- orders have become the focus of interest for ...