1. An isolated polynucleotide encoding an anti-Factor XI (FXI) antibody or biologically active fragment thereof, wherein the antibody or biologically active fragment thereof comprises: (a) an immunoglobulin heavy chain variable domain comprising three complementarity-determining regions (CDRs), wherein ...
2.6. Other Targets for Antibody-Directed Therapy Recent evidence suggests that the CD98 glycoprotein plays a key role in mediating cellular interaction of AML cells with their microenvironment thus promoting leukemogenesis and leukemic cell maintenance. Using patient derived AML cells and mouse models, ...