Immunoglobulin classes share the same basic four polypeptide chain structure of two heavy chains (five types) and two light chains (kappa, lambda; both having a molecular weight of 22.5 kDa). Kappa and lambda consist of a variable region and a constant region and can easily be...
Timofeeva AM, Buneva VN, Nevinsky GA (2015) Systemic lupus erythematosus: molecular cloning and analysis of 22 individual recombinant monoclonal kappa light chains specifically hydrolyzing human myelin basic protein. J. Mol. Recognit. 28: 614-627. https://doi.org/10.1002/jmr.2476 PMID: 25867248...
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Concentrations of the light chains kappa and lambda were determined by simple radial immunodiffusion in the blood sera of 437 patients with monoclonal gammopathies. The kappa/lambda index was calculated in monoclonal gammopathies with the antigenic type of kappa light chains, while in monoclonal gam...
Quantitation of immunoglobulins and light chains correctly typed 142 of 159 cases of monoclonal gammopathy. False-negative results were only seen in 17 cases of minimonoclonal gammopathies (IgG-kappa, IgG-lambda, and kappa light chain), in which either the quantitation of light chains or of ...
Background:High serum concentrations of monoclonal free light chain (FLC) kappa or lambda are markers of plasma cell dyscrasia. Methods:We developed new, latex-enhanced, specific nephelometric assays based on monoclonal antibodies for the determination of FLC kappa and lambda in serum, EDTA plasma...
Complete kappa-chain variable region sequences were determined for 10 light chains from anti-beta-(1,6)-D-galactan-binding monoclonal antibodies. Eight of these light chains were from IgM and two from IgG proteins. Seven of the eight IgM... M Pawlita,M Potter,S Rudikoff - 《Journal of ...
Immunoglobulin classes share the same basic four polypeptide chain structure of two heavy chains (five types) and two light chains (kappa, lambda; both having a molecular weight of 22.5 kDa). Kappa and lambda consist of a variable region and a constant region and can easily be differentiated ...
A second rabbit kappa isotype. J Exp Med 1982; 156: 585–595. 88 Bernstein KE, Skurla RM Jr., Mage RG. The sequences of rabbit kappa light chains of b4 and b5 allotypes differ more in their constant regions than in their 3' untranslated regions. Nucleic Acids Res 1983; 11: 7205–...
Lambda (l) - and kappa (k) - free light chains in multiple myeloma (MM) patients correlate with known monoclonal paraprotein, disease stage and therapy responseR�pple, DWeis, ADeschler, BBisse, EIhorst, GEnglehardt, M