monoclonal gammopathy of unknown originthe presence of a monoclonal pike in blood is very habitual in our daily medical activity. there are a lot of causes of that. if we know which kind of pathology had originated the monoclonal pike, we could be able to bring a suitable treatment and to...
These cells are of B-1 cell origin. The MG in Tg mice showed a later onset and a lower frequency than those in littermate control mice, mainly due to a four times lower frequency of benign monoclonal gammopathy. The 10% of B-1 cells that were able to produce endogenous Ig led to ...
We report a case whose interest, besides the rarity of the occurrence, rests in the pure papular expression of the clinical features, the association with a monoclonal gammopathy and the apparent efficacy of topical tacrolimus.关键词: alpha-Melanocyte-stimulating hormone Human skin autografts ...
A typically clinically asymptomatic precursor condition, monoclonal gammopathy of undetermined significance (MGUS), is thought to be the first pathogenetic step in the development of most, if not all MM5; however, the specific trigger that initiates the progression from MGUS to MM is unknown.5 ...
In 1% of the cases a double M-component is present which is referred to as a biclonal gammopathy. The pathogeneses of these disorders are unknown, but several possibly related environmental factors have been identified. In multiple myeloma, an increased incidence and mortality rate has been ...
67 Finally, in all patients treated with daratumumab, the appearance of a new IgG-κ band may represent daratumumab and should not be misinterpreted as disease recurrence, development of a new plasma cell malignancy, or development of a secondary monoclonal gammopathy of undetermined significance (...
MFC is also very useful also for research analyses focused on different aspects of B and plasma cell (PC) pathophysiology in term of MG development as well as in looking for potential myeloma-initiating cells. MFC thus should be included as a routine assay in monoclonal gammopathy patients. ...
Orbital marginal cell lymphoma and mantle cell lymphoma subclone in patient with monoclonal gammopathy of unknown significanceLymphoma transformationmantle Cell Lymphomamarginal Cell Lymphomaorbital LymphomaIndolent lymphomas have the potential to transform into more aggressive phenotypes. This phenomenon is best ...
Orbital marginal cell lymphoma and mantle cell lymphoma subclone in patient with monoclonal gammopathy of unknown significanceLymphoma transformationmantle Cell Lymphomamarginal Cell Lymphomaorbital LymphomaIndolent lymphomas have the potential to transform into more aggressive phenotypes. This phenomenon is best ...
Considering the differential for a pyrexia of unknown origin (PUO), causes were systematically worked through and excluded including infection, malignancy (though recognizing his haematological findings), autoimmune disease, granulomatous disease, vasculitides and auto-inflammatory conditions. The patient was...