monoclonal gammopathy of unknown originthe presence of a monoclonal pike in blood is very habitual in our daily medical activity. there are a lot of causes of that. if we know which kind of pathology had originated the monoclonal pike, we could be able to bring a suitable treatment and to...
These cells are of B-1 cell origin. The MG in Tg mice showed a later onset and a lower frequency than those in littermate control mice, mainly due to a four times lower frequency of benign monoclonal gammopathy. The 10% of B-1 cells that were able to produce endogenous Ig led to ...
Secondary monoclonal gammopathy of undetermined significance (MGUS) is a special phenomenon that occurs during the treatment of multiple myeloma (MM). The incidence, biological characteristics, and prognostic value of secondary MGUS in patients with MM remain undefined. We proceed with a retrospective sy...
•Sensitive(0.02g/dL)•Candetectheavyandlightchain•doesnotgiveanestimateofthesizeoftheM-protein 24-hoururineproteinelectrophoresis •amountofurinaryM-Procorrelatesdirectlywiththesizeoftheplasmacellburden(normalrenalfunction)determiningtheresponsetotherapy&progressionofdisease.M-Pro&Diseases •Plasmacell...
67 Finally, in all patients treated with daratumumab, the appearance of a new IgG-κ band may represent daratumumab and should not be misinterpreted as disease recurrence, development of a new plasma cell malignancy, or development of a secondary monoclonal gammopathy of undetermined significance (...
In 1% of the cases a double M-component is present which is referred to as a biclonal gammopathy. The pathogeneses of these disorders are unknown, but several possibly related environmental factors have been identified. In multiple myeloma, an increased incidence and mortality rate has been ...
MFC is also very useful also for research analyses focused on different aspects of B and plasma cell (PC) pathophysiology in term of MG development as well as in looking for potential myeloma-initiating cells. MFC thus should be included as a routine assay in monoclonal gammopathy patients. ...
We report a fatal case of ECD with extensive cardiac involvement associated with a marginal zone lymphoma and monoclonal proteinemia in a young man. This is the first reported association of ECD with a monoclonal gammopathy or a lymphoma.
1 Recent protocols of intensive chemotherapy, sometimes with an autologous BM transplant, have improved initial response, although long-term survival remains to be assessed.2 Although monoclonal gammopathy of undetermined significance (MGUS) also involves monoclonal plasma cells, the clinical manifestations ...
Orbital marginal cell lymphoma and mantle cell lymphoma subclone in patient with monoclonal gammopathy of unknown significanceLymphoma transformationmantle Cell Lymphomamarginal Cell Lymphomaorbital LymphomaIndolent lymphomas have the potential to transform into more aggressive phenotypes. This phenomenon is best ...