Monoclonal gammopathy was detected in sera of nine patients with liver cirrhosis but no evidence of lymphoproliferative disorders. The type of M-protein was IgG kappa in four, IgM lambda in three and IgA kappa in two patients. Only one patient had Bence-Jones proteinuria. In all pat...
Vejlgaard T, Abildgaard N, Jans H, Nielsen JL, Heickendorff L. Abnormal bone turnover in monoclonal gammopathy of undetermined significance: analyses of type I collagen telopeptide, osteocalcin, bone-specific alkaline phosphatase and propeptides of type I and type III procollagens. Eur J Haemat...
One IgG-2 kappa M-component showed extremely high anti-ds DNA, anti-Sm, anti-F(ab')2 and anti-Sm/ RNP ELISA activity. Cross inhibition studies showed that each reactive antigen inhibited the other. N-terminal V-region sequencing showed the VH3, VK3 subgroup. Anti-idiotypic rabbit ...
Circulating immunoglobulin (Ig) secreting cells of each type of the different Ig classes were enumerated using a reverse haemolytic plaque assay in nine subjects with the pre-clinical phase of IgG myeloma (six with benign monoclonal gammopathy and three with smouldering multiple myeloma). A shift in...
Serum protein electrophoresis and immunofixation from a patient with an IgM kappa monoclonal gammopathy (arrow). Table 25.1. Classification of monoclonal gammopathies 1. Malignant monoclonal gammopathies • Multiple myeloma (overt, smoldering, osteosclerotic, nonsecretory) • Plasmocytoma (...
a homogeneous immunoglobulin resulting from the proliferation of a single clone of plasma cells; during electrophoresis of serum, it appears as a narrow band or "spike"; it is characterized by heavy chains of a single class and subclass and by light chains of a single type. ...
monoclonal gammopathy of renal significance; MIDD, monoclonal immunoglobulin deposition disease (Randall-type); MM, multiple myeloma; MPGN, membranoproliferative glomerulonephritis; NS, nephrotic syndrome; PGNMID, proliferative glomerulonephritis with monoclonal immunoglobulin deposits; TBM, tubular basement membran...
Monoclonal gammopathy of undetermined significance MM: Multiple myeloma PC: Plasma cell PID: Primary inherited immunodeficienc6y POEMS: Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Protein, Skin Changes POEMS-MCD: POEMS-associated MCD
Neuropathy has been frequently reported in patients with IgG monoclonal gammopathy of undetermined significance (MGUS) but it is still unclear whether this association has clinical or pathogenetic relevance. In order to clarify the possible role of IgG MGUS in the neuropathy we correlated the clinical...
1.Kyle RA, Durie BG, Rajkumar SV, Landgren O, Blade J, Merlini G, et al. Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asyntomatic) multiple myeloma: IMWG consensus perspectives risk factors progression and guidelines for monitoring and management. Leukemia 2010;24:1121...