CD10 (Common Acute Lymphocytic Leukemia Antigen, CALLA), is a cell surface enzyme with neutral metalloendopeptidase activity which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, immature...
Re-analysis using polyclonal antibodies against SIg light chains, revealed presence of lambda light chains on the CD10positive B-cells. Conclusions These data illustrate when antibodies against SIg light chains are employed for B-cell clonality assessment, polyclonal antibodies are preferred over ...
T-cell clones were not identified in lymphomas other than B-cell post-transplant lymphoproliferative disorders. Among 53.8% cases of EBV-positive B-cell post-transplant lymphoproliferative disorders with associated clonal expansion of T-cells tested, none had EBV-positive T cells. We conclude that ...
they can be used to kill the target cell by antibody-dependent cell-mediated cytotoxicity (ADCC). For example, in B-cell cancer of mouse, monoclonal antibodies targeted towards CD20 andCD10 antigensinducedADCCor complement-mediatedcell lysis. Some antitumor effects ofrituximab(a monoclonal antibody...
Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered. 靶标信息 Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activ...
SC3 monoclonal antibody defines a novel specific human B-cell surface antigen differentially expressed on B-cell leukaemias and lymphomas and involved in the proliferation of normal and malignant B lymphocytes 文档格式: .pdf 文档大小: 440.54K
A prospective study of positive/negative ex vivo B-cell depletion in patients with chronic lymphocytic leukemia Objective Autologous peripheral blood stem cell (PBSC) transplantation is increasingly being used in patients with chronic lymphocytic leukemia (CLL). As t... Peter,Dreger,and,... - 《...
Monoclonal antibodies are most frequently generated in mice by administration of the “antigen” and subsequent isolation of B-cells that make antibodies. The B-cells are then immortalized by fusion to another, stable cell type of the same species of the B cell to create a “hybridoma”. An ...
Some molecular experiments showed that tetraspanins may interfere with the properties (affinity of the integrin α6β1 for laminin-1 is modulated by the tetraspanin CD151) [9], the trafficking (CD81 controls the expression of CD19 at the B-lymphoid cell surface) [10] or membrane ...
Basophils were identified as CD123++HLA-DR−. Double staining of basophils and mast cells with toluidine blue and immunofluorescence. Expression of cell surface antigens on basophils (n = 3) and tissue mast cells (lung, n = 3; foreskin, n = 3; uterus, n = 3) was analyzed by ...