Introduction: Monoclonal antibodies (MoAbs), non-chemotherapeutic agents targeting the antigens present on chronic lymphocytic leukemia (CLL) lymphocytes, are being implemented increasingly more often as treatment options.Korycka-Wolowiec, AnnaWolowiec, DariuszRobak, Tadeusz...
Chronic lymphocytic leukemia (CLL) represents the most prevalent adult leukemia. Treatment with chemotherapy over the past 3 decades has been palliative. The introduction of therapeutic antibodies has increased the number of treatment options for this disease. Despite this increase, our true understanding...
In recent years, monoclonal antibodies (mAbs), as potent antitumor tools, have gained increasing importance in the clinic. The use of antibody engineering methods has made it possible for investigators to develop antibody structures with improved antitumor effects. The development of efficacious therapeut...
Monoclonal antibodies in the treatment of chronic lymphoid leukemias - Robak - 2004 () Citation Context ...e CR Median response duration References 44% 0% PFS -106d Coiffier et al.(6) FA ref58% BFref - 47% BFref1pt FA ref-5.7m BFref-5.9m Wierda et al. (8) 62% 0% NR ...
"By targeting CD44, it may be possible to kill CLL cells regardless of whether there are sufficient numbers of so-called 'effector cells,' which ordinarily are required by othermonoclonal antibodiesto kill tumor cells," said Kipps. "We plan to initiate clinical trials using this humanized anti...
Immunoglobulins (Ig) or antibodies are heavy plasma proteins, with sugar chains added to amino-acid residues by N-linked glycosylation and occasionally by O-linked glycosylation. The versatility of antibodies is demonstrated by the various functions that
Antibodies containing uniform variable regions and thus specific for a single epitope. Originally, monoclonal antibodies were derived from a single B lymphocyte clone. Genetic manipulation now allows genes from multiple sources of B lymphocytes (for example, mouse and human) to be combined. ...
Cure of patients with chronic lymphocytic leukemia (CLL) has been an elusive goal. The recent availability of active monoclonal antibodies has rekindled enthusiasm for new and innovative therapeutic approaches. Alemtuzumab, induces responses in about a third of patients with relapsed or refractory CLL ...
Monoclonal antibodies are multivalent proteins that have a high affinity and selectivity for specific antigenic epitopes. They can be used to induce antitumor effects through various mechanisms such as complement-mediated cytotoxicity, cell-mediated cytotoxicity, apoptosis induction, inhibition of protein inte...
Monoclonal antibodies are also provided which are specific for the glucosylated terminal peptide sequence in the beta-subunit of human hemoglobin and are therefore useful in the determination of Hb Alc.WILLIAM KNOWLES... W Knowles,V Marchesi,W Haigh 被引量: 0发表: 1986年 Clinical Significance of...