All-trans retinoic acid is known to inhibit adipocyte differentiation, whereas, molecules activating the retinoid X receptor (rexinoids) promote the differentiation of adipocytes. Treatment with rexinoids ameliorates glycemic control in rodent models of type II diabetes and obesity, although other ...
Examples of Monoclonal Antibodies Used to Treat Hematologic Malignancies Antibody NameTrade NameAntigenUsed to treat Rituximab Rituxan CD20 Non-Hodgkin lymphoma, B-cell type Ofatumumab Arzerra CD20 Chronic lymphocytic leukemia Alemtuzumab Campath CD52 B- and T-cell malignancies Ibritumomab tiuxetan (radio...
Monoclonal antibodydrugs are cancer treatment therapies that include naturalimmune system functionsto fight cancer. Unconjugated or “Naked monoclonal antibodies”, conjugatedmonoclonal antibodies, bi- and trispecific monoclonal antibodies are different types of monoclonal antibodies as per their utility. Dependi...
Monoclonal antibody development has had revolutionary success in the generation of therapeutic drugs for treatment of conditions such as cancer, asthma, Crohn’s disease, psoriasis, and many other infectious and inflammatory diseases. However, monoclonal antibodies are also useful as a to...
Expression of MCL1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g. ionizing radiation, ultraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in bcl-2. Enhanced expression of MCL1, prominently associated with ...
Monoclonal antibodies (mAbs) have become increasingly important as human therapeutic agents. Yet, current research concentrates on technology itself and pays attention to developed countries. This paper aims to provide a comprehensive review of mAbs development in China through systematic analysis of drug...
Although these targets have typically been the domain of small-molecule drugs, the exquisite specificity of monoclonal antibodies offers a significant opportunity to selectively modulate these target proteins. Nevertheless, the isolation of antibodies with desired pharmacological functions has proved difficult ...
Pfizer CentreOne offers production of therapeutic proteins including monoclonal antibodies (mAbs), bi-specific clonal antibodies (BsAbs) fusion proteins & native proteins, with or without conjugation to payloads or half-life extenders (e.g. PEG).Category : Biologic Drugs Sub Category : ...
which involves either CGRP receptor antagonists or monoclonal antibodies (mAbs) to CGRP or its receptor, has recently shown clinical efficacy in migraine management. The site of action, although still being studied, is likely in nervous system structures outside the blood–brain barrier. To date, ...
Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs ...