From the 2000s, an additional mechanism of action of MAO-A has been proposed. Such mechanism involves hydrogen peroxide (H2O2) production during substrate degradation. This finding stimulated a growing interest on the role of MAO-A-dependent oxidative stress in cardiac pathophysiology. Al...
What are monoamine oxidase inhibitors (MAOIs)? How do they work (mechanism of action)? MAOIs were the first class ofantidepressantsto be developed. They fell out of favor because of concerns about interactions with certain foods and numerousdrug interactions. MAOIs elevate the levels of norepinep...
Rinaldi D, Alborghetti M, Bianchini E, Sforza M, Galli S, Pontieri FE (2022) Monoamine-oxidase type B-Inhibitors and cognitive functions in Parkinson’s disease: beyond the Primary Mechanism of Action. Curr Neuropharmacol. https://doi.org/10.2174/1570159X20666220905102144 Article Google Scholar ...
The development of monoamine oxidase (MAO) inhibitors has followed a winding path. At the origin was the finding of E. A. Zeller that iproniazid, a hydrazine derivative designed to improve the tuberculostatic action of isoniazid, caused potent inhibition of MAO in vitro and in vivo. The inh...
The mechanism of action of MAOIs involves the inhibition of the monoamine oxidase enzyme, thereby preventing the breakdown of serotonin, norepinephrine, and dopamine (and in the intestine, tyramine), leading to their increased concentrations in the central nervous system. The MAO-A enzyme ...
They concluded from this result that: (1) Monoamine oxidase-inhibiting hydrazines have a similar and practically synchronous effect on 5-HIAA excretion after loading with serotonin and 5-HIAA. (2) This effect is brought about through the same mechanism of action. (3) The action of the so-...
Molecules men whose average age was 33.5±8.8 years (range: 23–50) showing this mechanism of action are classified as RIMAs, and average BMI 25.4±1.8 kg/m2 (range: 25.4–28.5) were or reversible inhibitors of MAO-A, to distinguish them from enrolled after informed consent was obtained ...
MOA (Mechanism of Action) ▪ MAO degrades catecholamines, serotonin, and other endogenous amines in the CNS as well as in the periphery. ▪ There are two key isoenzymes: ▴ MAO-A degrades epinephrine, norepinephrine, and serotonin. ▴ MAO-B degrades phenylethylamine. ▴ Both degrade...
The anticonvulsant agent milacemide (2-(n-pentylamino)acetamide) is known to inactivate monoamine oxidase-B (MAO-B). Various isotopically labeled analogues of milacemide are used to elucidate the mechanism of inactivation of MAO-B by this compound. The metabolites of the oxidation of milace...
S Garattini W Buczko A Jori R Samanin (1975) The mechanism of action of fenfluramine. Postgrad Med J 51 27–35 768968 PubMed Google Scholar S Garattini S Caccia T Mennini R Samanin S Consolo Ladinsky (1979) Biochemical pharmacology of the anorectic drug fenfluramine: a review. Cu...