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Modification succeeded in 13 of 20 blastocysts (65%), 8 of which (40.0%) were monoallelic modifications and 5 (25.0%) were biallelic modifications. Based on high mutation rates in blastocysts, we transferred the cloned embryos to 5 recipient pigs; 1 recipient was pregnant and 16 fetuses were...
Other genes also falling into the randomly monoallelically expressed class have some cells with biallelic expression in addition to the cells with monoallelic expression. Here for the most part, we are talking about an all or none pattern such that the non- expressed alleles appear to be ...
identified a monoallelic germline c.934-2A > G splice site mutation inMUTYH.In vitro, magnesium deficiency potentiated oxidative DNA damage in lymphoblastoid cell lines derived from the same patient. We postulate that monoallelicMUTYHmutations may manifest in the presence of cooperative non-geneti...