Now, researchers present a high-resolution structure of the monkeypox virus DNA polymerase holoenzyme—a complex that plays a key role in the genome replication process of the virus. The findings reveal the mechanism that underlies monkeypox virus genome replication and could be used to guide the ...
The World Health Organization announced mpox(or monkeypox)as a public health emergency of international concern in July 2022,and prophylactic and therapeutic measures are in urgent need.The monkeypox virus(MPXV)has its own DNA polymerase F8,together with the processive cofactors A22 and E4,...
in situ structural insights into major structural proteins and assembly of the authentic MPXV particles are missing. Early electron microscopy (EM) micrographs of the negative-stained or resin-embedded MPXV mature virus (MV), the basic form of infectious MPXV particles, have revealed...
The structure ofmonkeypoxvirus (MPXV), like that of otherorthopoxviruses, displays that virions are brick-shaped (ovoid) particles with a size range between 200 and 250 nm, capsid encompassed by a spatially perforatedlipoproteinouter membrane(envelope) [17]. The virus has distinctsurfacetubules a...
Monkeypox virus (MPXV), which causes disease in humans, has for many years been restricted to the African continent, with only a handful of sporadic cases in other parts of the world. However, unprecedented outbreaks of monkeypox in non-endemic regions h
Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8 J. Biol. Chem., 293 (2018), pp. 390-401 View PDFView articleView in ScopusGoogle Scholar McCollum and Damon, 2014 A.M. McCollum, I.K. Damon Human monkeypox Clin. Infect. Dis.,...
Singh has been studying virology and DNA genome replication for nearly 30 years. He said the homology, or structure, of the monkeypox virus is very similar to the vaccinia virus, which has been used as a vaccine to treat smallpox. This enabled Singh and his collaborators to create an ...
Species-specific differences in the structure of orthopoxvirus complement-binding protein. Virus Res. 2001;81:39–45. https://doi.org/10.1016/S0168-1702(01)00332-X. Article CAS PubMed Google Scholar Al-Musa A, Chou J, LaBere B. The resurgence of a neglected orthopoxvirus: immunologic ...
Monkeypox virus DRC: Democratic Republic of the Congo PHEIC: Public health emergency of international concern HZ: Health zone GLMM: Generalized linear mixed model LASSO: Least absolute shrinkage and selection operator NB: Negative binomial IRRs: Incidence rate ratios CIs: Confidence interva...
Under an electron microscope, Mpox has a recognizable oval or brick-shaped structure with a lipoprotein envelope that ranges in size from 200 to 400 nm. Despite being a DNA virus, Mpox completes its life inside infected cells after binding on glycosaminoglycans and entering the host cells. To...