A29L是细胞内成熟病毒(IMV)表面包膜蛋白(与牛痘病毒VACV,A27同源)。溶瘤痘苗病毒(VV)属于痘病毒科中一拥有192kb双螺旋DNA遗传物质的病毒,会在细胞质中繁殖出具有鞘膜的病毒,进而感染其他不同种的哺乳动物细胞及个体.VV中的A27L基因能表达出一14kDa大小的鞘膜蛋白,此蛋白能与细胞表面上的硫酸乙酰肝素(Heparan Sul...
The attenuated virus can enhance the ability of the human body to fight monkeypox virus. In 2003, three patents of detecting monkeypox virus were published (WO2003066807, US20030211964 and WO2003046221), describing the identification of monkeypox virus by DNA-DNA and Z-DNA. In 2004, patents ...
The term micro-outbreak that we used in our article corresponds to us to outbreak with less that ten human cases. Isolation of MPXV, DNA extraction and molecular assays Two MPXV isolates (A1 and A2; Table 1) were isolated and amplified after one passage of intracranial inoculation in the ...
Utilizing flow cytometry, we analyzed the DNA content changes in two diploid human cell strains and two monkey cell lines. The osteogenesis imperfects (OI) human skin fibroblasts were induced into DNA synthesis, and within one to two cell generations, a polyploid cell population was produced. ...
(DREADD) technology to manipulate the neural activity in the STN of macaque monkeys. Although DREADDs have been utilized widely in rodents, application in sub-human primates is rather limited and only one electrophysiologic evaluation at the single-neuron level28is reported. Here, we showed that ...
DNA base sequence comparisons demonstrate that the principal family of 300-nucleotide interspersed human DNA sequences, the repetitive double-strand region... WR Jelinek,TP Toomey,L Leinwand,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 819发...
The available database demonstrates repeated nucleic acid sequences are common in the human genome. Repeated DNA is required for centromere function in Shi... KM Fischer 被引量: 0发表: 0年 Nucleotide sequence analysis and enhancer function of long terminal repeats associated with an endogenous Afri...
(Mutation residues: C25S, C130S) were obtained by point mutation using MPXV M2 DNA as a template. The genes encoding mouse B7.1 (mB7.1) and B7.2 (mB7.2) were amplified from the cDNA of C57BL/10 mouse spleen cells. The coding sequences of human CD28, PD-L1, PD-L2, B7-H3, B7-...
Joller, N.et al. (2011) J. Immunol.83:1338. Long Name T Cell Immunoreceptor with Ig and ITIM Domains Entrez Gene IDs 201633 (Human); 100043314 (Mouse); 363784 (Rat); 102121588 (Cynomolgus Monkey) Alternate Names T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3; WU...
monkey and human colonic organoids to test the toxicity response of anti-cancer drugs. Three types of organoids were seeded into 96 well plates in DM. Then, two clinically used anti-colon cancer drugs irinotecan (a DNA topoisomerase inhibitor) and regorafenib (a multi-targeted receptor tyrosine...