A highly feasible and reliable ultra‐high performance liquid chromatography tandem mass spectrometry method was presented for therapeutic drug monitoring of five anti‐schizophrenic drugs (amisulpride, olanzapine, aripiprazole, paliperidone and ziprasidone) simultaneously. To meet the requirements of practical ...
Sulpiride appears to have a therapeutic ‘window’ with an upper limit around 1.5 µmol/L. The interindividual variations in plasma sulpiride concentrations appear to be relatively small compared with other antipsychotic drugs and hence may limit the clinical requirements, if any, of plasma level ...
The present work demonstrates that MALDI-SRM/MSI is quantitative with precision better than 10–15 %, which meets the requirements of most guidelines (i.e., in bioanalysis or toxicology) for quantification of drugs or peptides from tissue homogenates. MALDI-SRM/MSI is quantitative with precision...