In addition, we are not well equipped with the newer antibiotics to cope the surge of MDR, XDR, and PDR pathogens as the potent antibiotics are depleting in healthcare facilities. Though the situation demands a quick action to discover novel antibiotics, some efforts have been done to save ...
The RASG12V mutation is found in cancers such as lung cancer and pancreatic cancer, for which there are often no suitable therapies [16]. RAS mutants cannot be blocked as one blocks typical oncogenic proteins because this oncogene loses its GTPase activity as a result of the mutation. The ...
a glycolytic enzyme, found in many parasites, has been identified as one of the candidate molecules distinguished from human counterparts for vaccine and dru... SJ Hong,KY Seong,WM Sohn,... - 《Molecular & Biochemical Parasitology》 被引量: 161发表: 2000年 Gene expression profile of CD4+ T...
Though much progress in healthcare has been made with biologics, end-user access to these innovative drugs is gradually being ignored or, at least, seldom prioritized. On this personal but justifiable perception lies the essence of this appraisal. 2. Some innovative breakthroughs More than ever, ...
The cost for patent-protected medication became an increasing burden for healthcare systems. Today, healthcare providers and payers are no longer capable or willing to afford premium prices for drugs that cannot prove therapeutic benefits over the standard of care in the respective indication. As a...
Combined with a vaccine, particularly for anyone at high risk such as those in healthcare settings, it could put a stop to the whole thing — and might also turn out to be effective on other, less deadly but still annoying, viruses. But, I hear you ask, what is it? Because if I’...
11 reviewed in Löfblom et al.12 The Affibody molecule is very robust, and has generated useful biotech tools, for example, as the alkali-resistant active component in MabSelect SuRe for affinity purification of mAbs (MabSelect SuRe, Catalog number 17-5438-01, GE Healthcare, Chicago, IL,...
Ferritin (MW = 440 kDa; pI = 5.1–5.7) and thyroglobulin (MW = 669 kDa; pI = 4.7) were purchased from GE Healthcare. A concentration of 28 nM of the protein solution in PBS (pH 7.4, Sigma-Aldrich) was used. DNA fragments (MW = 650 Da × number ...
The sequence candidates were found in three iterations using the modifications of the following parameters: max target sequence of 5000, expected threshold of 1 × 10−3, PSI-BLAST threshold of 1 × 10−40, and low complexity filter masking. Homo sapiens ANX (ANXA5 and ANXA4) and SP (...
Of particular importance is the increase in interest in the application of these species in cosmetic products [1,2]. The habitats of different Artemisia ssp. differ from one another and are widely distributed. Natural habitats of these species are found in Europe, Asia, North Africa, North and...