Full size image Table 1 Medicinal chemistry progression of the screening hit 1 to VX-147 Full size table APOL1 risk variants lead to increased channel activity We hypothesized that the enhanced toxicity related to APOL1 G1 and G2 was the result of increased ion flux. Indeed, in the thallium...
We start by demonstrating visually the effect of the MW size. For that, we recorded the images for MW = 30, 35, 55, 135 and 195. We superimposed these images with the GT data, where the results of tcSMLM are shown in green, SMLM in red and both are shown in relation to the...
Full size image We first explored the capabilities of our multi-color flat-field SIM setup by imaging a dye solution containing fluorescein, Texas Red and ATTO 655, respectively. Each illumination mode (HILO, GI, TIR) can be sequentially switched by the SLM without the need of any further op...
The localizations were converted from nm to voxels through dividing the spatial coordinates of each localization by the voxel size and rounding to the nearest integer value. The voxel values for each localization were then used to determine the chromatin density class, and distance from the edge ...
Interactions of antifouling monolayers: Energy transfer from excited albumin molecule to phenol red dyeingentaconnectCHEMICAL PAPERS- SLOVAK ACADEMY OF SCIENCESXuH.WallaceR.HepelM.
Download: Download full-size image Figure 1. Illumstration of smFRET, smPIFE, and SiMPull (A) When a protein filament assembles on a single-stranded DNA separating the donor (green) and the acceptor fluorophore (red) one monomer at a time, a stepwise decrease in FRET is observed over ...
Sample Applications Environmental: EPA Method 1694, Illicit and prescribed drugs in wastewater Food Safety: Quinolone antibiotics Pharmaceutical: Chloramphenicol, Simvastatin, Chrysophenol (TCM), amphetamine, ranitidine Double Endcapped (except PAH, which is not endcapped) Temp limit: 60 °C Pore size: ...
The cells were then pelleted in the plate and resuspended in 50 μl of PBMC FACS buffer (RPMI 1640 without phenol red + 10% FBS + 0.1% NaN3). A 10-μl aliquot of each of the PE-labeled 2D7 and PerCP-labeled anti-CD4 mAbs, or the appropriate PE- and PerCP-labeled isotype ...
Full size image A small molecule-nanobody conjugate is usually not cell-permeable and cannot be directly employed to regulate cellular processes inside living cells. Traditional intracellular delivery modules such as linear cell-penetrating peptides (CPPs)18 and other more elegant biocompatible cargos ...
b CD86–mEos3.2 and CD28–mEos3.2 before (black line) and after antibody treatment (red line). The dashed lines indicate the peak of each colored line. Full size image Then, to detect homodimerization, we used CD28–mEos3.2 and CD86–mEos3.2, which were later labeled with anti-CD28 ...