The identification of LIF as a molecule, necessary and sufficient for the maintenance of ES cells in culture, should have a profound impact on the use of these cells for genetic manipulations. 展开 关键词: Animals Humans Mice Cells, Cultured Leukemia, Myeloid Growth Inhibitors Recombinant Proteins...
1a,b). The loss of KIF18A had a significant effect on the growth of TP53-mutant CCNE1-amplified cell lines (HCC-1806, MDA-MB-157, OVCAR-3) and retinoblastoma protein (Rb)-deficient BT-549 cells24. However, it had only a modest impact on the growth of TP53-wild-type (WT) or ...
After G-CSF alone, CXCR-4 expression on patients' blood and marrow CD34+ cells was significantly lower than in the healthy controls (p < 0.001), but allowed no prediction of stem cell yield. Except in the single poorly mobilising patient, AMD3100 led to a further significant decrease of ...
Metabolite biosignatures from human biofluids providing a link between genotype, environment and phenotype, are attractive biomarkers for the clinical diagnosis, prognosis, and diseases classification.1,2,3,4,5,6,7,8It can provide a unique metabolic readout and snapshot of the health/disease status...
A multidomain compound with applications in the area of organic solar cells has been prepared. This all-in-one molecule compound integrates all the functionalities needed for solar cell action from light harvesting, carrier generation, and separation, to transport and contact to external electrodes. ...
Epithelial cell motility of confluent monolayers is characterized by subtle cell shape changes and variations in the cell-substrate as well as cell-cell distance without net directionality of individual cells. The impact of small molecules such as cytochalasin D, phalloidin, and blebbistatin as well ...
In the current study, (1) rat cortical neurons (RCNs) were used as the cellular basis for investigation and (2) were either seeded with hAD tau or left as unseeded unseeded. Cells were (3) treated with 8 μm Anle138b for three different durations then (4) RNA-Seq experiments were ...
Solution processable small-molecule organic solar cells have progressed a lot in terms of donor and acceptor materials, device architectures, fabrication techniques, and optimization methodologies which have enabled credible performance gains. The hierarchical active layer morphology is one such strategy that...
1b and Supplementary Fig. 1a). To determine whether the block in filamentation was due to compromised cell viability, C. albicans cells grown in Lactobacillus-conditioned medium were incubated with propidium iodide, a red-fluorescent DNA-binding dye only permeable to dead cells. Lactobacillus-...
cells. Mechanistically, MIC acts by inhibiting ligand-induced activation of the nuclear hormone receptor DAF-12/FXR, which, in turn, induces mitophagy and extends lifespan. In conclusion, our study uncovers MIC as a promising drug-like molecule that enhances mitochondrial function and extends life...