characterization of the spatial organization and interactions of molecular defined cell types. For example, the layered organization of the cerebral cortex and the nucleus organization in the hypothalamus directly impact their functions. At a finer scale, spatial relationship between cells is a major det...
The enormous diversity and intricate organization of cells have impeded our understanding of the molecular and cellular basis of brain function. Recent advances in spatially resolved single-cell transcriptomics have enabled systematic mapping of the spatial organization of molecularly defined cell types in...
We defined a panel of nine antibodies to test the spatial heterogeneity of microglia in relation to Aβ plaques and PHF-1-positive NFTs (Fig. 4). We showed that each antibody could each be de-stained and the cross-reactive was effectively blocked using the refined MICSSS protocol. Moreover...
Cancer is a disease caused by abnormal cell growth that spreads through other parts of the body and threatens life by destroying healthy tissues. Therefore, numerous techniques have been employed not only to diagnose and monitor the progress of cancer in a precise manner but also to develop appro...
Methods for assembling metal nanoparticles into symmetrically and spatially well-defined architectures are important because new properties often emerge from the particle aggregate that are distinctly different from the corresponding isolated nanoparticles. For example, collective nanoparticle behaviors are ...
polymerization (NMP) (10, 11), and iniferter-induced polymerization (12) allow the generation of reactive chains that can undergo reversible propagation–termination cycles with the added advantage of controlled chain growth leading to the formation of more stable and well-defined cavities in MIPs (...
We developed and validated our approach in vivo by non-invasively modulating the propagation of neuronal activity through a defined cortical microcircuit, specifically the rodent vibrissae sensory-motor pathway25,26. We manipulate this circuit by focally inhibiting vibrissa sensory cortex, through ultrasoun...
We defined a panel of nine antibodies to test the spatial heterogeneity of microglia in relation to Aβ plaques and PHF-1-positive NFTs (Fig. 4). We showed that each anti- body could each be de-stained and the cross-reactive was effectively blocked using the refined MICSSS proto- col...
In addition to the traditional case of surface excitation, we also consider the case where carrier generation is spatially uniform. In our analysis, the front electrode is treated as a reflecting boundary, while the counter electrode is assumed to act either as a neutral contact (not disturbing ...
Based on the well-defined PS_(10)-b-PMMA_(130)/PCBM nanostructure, resistive random access memory (ReRAM) exhibits significantly improved bipolar-switching behavior with stable and reproducible properties at low operating voltages (RESET at 1.3 V and SET at -1.5 V) under ambient conditions. ...