40 μm.cThe ABR results of the GPR156-shRNA-injected ear (n = 9 mice), the contralateral ear (n = 9 mice), WT mice (n = 4 mice) and AAV-control-injected
40 μm.cThe ABR results of the GPR156-shRNA-injected ear (n = 9 mice), the contralateral ear (n = 9 mice), WT mice (n = 4 mice) and AAV-control-injected
In the cultured cells, H2 suppressed free radical chain reaction-dependent peroxidation and recovered the increased cellular Ca2+, resulting in the regulation of Ca2+-dependent gene expression. Thus, H2 might regulate gene expression via the Ca2+ signal transduction pathway by modifying the free ...
Significantly enhanced photocatalytic efficiency of ZIF-8 for pollutants degradation was obtained after SPPy conjunction. 2 wt%SPPy/ZIF-8 heterojunction was the optimum photocatalyst, showing highest degradation efficiency (98.5% in 90 min and 92.7% in 150 min for CR and AMX, respectively). The ...
We chose the sequence of the PUMA BH3 domain (wild-type (WT) PUMA) (Fig. 3a,b and Supplementary Data 1) because its residual helicity is a well-studied example of functionally linked structural biases in IDPs6,24. We first established the previously reported short-range helical structural ...
Name Formula [mol/molair ] [vol%] [g/mol], [kg/kmol] [g/molair ], [kg/kmolair ] [wt%] [K] [°C] [°F] Nitrogen N2 0.78084 78.084 28.013 21.872266 75.511 77.4 -195.8 -320.4 Oxygen O2 0.20946 20.946 31.999 6.701942 23.14 90.2 -183.0 -297.3 Argon Ar 0.00934 0.934 39.948 0.373...
质谱分析证实,与PIK3CAWT/WT细胞相比,PIK3CAH1047L/H1047L和PIK3CAWT/H1047L细胞的PI(3,4,5)P3水平升高。PI(3,4,5)P3去磷酸化可以通过PTEN或SHIP1/2发生。PTEN的敲除导致了整个细胞表面的PI(3,4,5)P3水平的增加,同时削弱了其区域化分布。研究人员进一步观察了突变细胞中AKT的分布,结果表明IA类PI3K和PTEN...
molecules Review Emerging Cytotoxic Alkaloids in the Battle against Cancer: Overview of Molecular Mechanisms Zeina Habli 1,†, Georgio Toumieh 1,†, Maamoun Fatfat 1, Omar Nasser Rahal 2 and Hala Gali-Muhtasib 1,* 1 Department of Biology and Department of Anatomy, Ce...
The triplet microtubule, a core structure of centrioles crucial for the organization of centrosomes, cilia, and flagella, consists of unclosed incomplete microtubules. The mechanisms of its assembly represent a fundamental open question in biology. Here,
The spread of α-Syn was evaluated three months after the injection. Results We found that the uptake of both monomeric and oligomeric α-Syn was significantly reduced in iPSNs with LRP1-KO compared with the WT controls. The uptake of α-Syn PFFs was also inhibited in LRP1-KO iPSNs, ...