Study of the interactions established between the viral glycoproteins and their host receptors is of critical importance for a better understanding of virus entry into cells. The novel coronavirus SARS-CoV-2 entry into host cells is mediat
The glucagon-like peptide-1 (GLP-1) receptor is a validated drug target for metabolic disorders. Ago-allosteric modulators are capable of acting both as agonists on their own and as efficacy enhancers of orthosteric ligands. However, the molecular details of ago-allosterism remain elusive. Here,...
cellular, and molecular analyses are used to investigate sex differentiation and to infer the genetic sex of an individual. For the purposes of this review, sex determination is used to describe the genetic and environmental processes and variables...
Chen WT, Chen JM, Mueller SC (1986) Coupled expression and colocalization of 140K cell adhesion molecules, fibronectin, and laminin during morphogenesis and cytodifferentiation of chick lung cells. J cell Biol 103:1073–1090 ArticlePubMedCASGoogle Scholar Chen CQ, Xin H, Zhu YZ (2007) Hydroge...
Interestingly, the nsP1-m7GMP structure was obtained when we incubated nsP1 with a 12-mer RNA from the 5′ end of the CHIKV viral genome with a Cap-0 structure at the 5′ end (m7GpppAUGGCUGCGUGA, hereafter named m7GpppAU-10). This indicates that wild-type (WT) nsP1 can cleave ...
When cotransfected with a CRE-luciferase reporter plasmid, CREBSA significantly inhibited CREB activity in cells; by contrast, CREBYF was five times more active than CREBWT (Figure 8B). Acute expression of constitutively active CREB in hippocampal neurons increased the protein levels of KIF17, ...
Cancer is a complex disease where various types of molecular aberrations drive the development and progression of malignancies. Large-scale screenings of multiple types of molecular aberrations (e.g., mutations, copy number variations, DNA methylations,
Using molecular simulation, we investigate the effect of nitrogen doping on adsorption capacity and selectivity of CO2 versus N2 in model mesoporous carbon. We show that nitrogen doping greatly enhances CO2 adsorption capacity; with a 7 wt % dopant concentration, the adsorption capacity at 1 bar an...
Synthesis of ideal UiO-66 The preparation of ideal UiO-66 follows the procedure described in ref. 42. 5.39 g terephthalic acid (Energy Chemical, China), 3.78 g zirconium tetrachloride (Aladdin, China), and 2.86 mL hydrochloric acid (36-38 wt.%, SCR, China) were added in a ...
respectively. Note that IP forbwas carried out using a mixture of lysates from cells transfected separately with each of the indicated constructs and that the provision of HA-Cep63 greatly increased the level of coprecipitated HA-Cep152 (see also the Supplementary Fig.1ilegend). GFP-Cep152 M4...