Alkylated imidazoles of high molecular weight are prepared by treating on imidazole which contains the atomic grouping wherein R stands for an aromatic nucleus, other than a benzimidazole or naphthimidazole substituted at the m -carbon atom by an aliphatic residue having at least three carbon ...
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(2)第二个例子是来自BACE数据集 human β-secretase 1抑制剂。该分子更加关注amidine, carboxamide和secondary ketimine,这些官能团形成imidazole成分。除此之外,pyridyl和phenyl也获得了更多关注。这些发现和以前的研究结果一致,imidazole抑制human β-secretase 1 (3)第三个样本来自FreeSolv,重点研究了水中小分子的水化自...
The green areas in the isosurfaces indicate the existence of (1) C–H···O weak hydrogen bonds and (2) π–π stacking interactions of the imidazole rings in His moiety and aromatic ring in CTC. The marked atoms of CDHis and CTC according to their contributions to the molecular ...
(RASGRP1, 180 nM each) and GAP (RASA1, 180 nM each) proteins in buffer B [50 mM Tris·HCl (pH 7.4), 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, and 20 mM imidazole] containing [γ-35S]-GTP (11 μM) in the absence or presence of increasing concentrations of KRA...
The cardiac fibers were separated in a small Petri dish filled with buffer (7.23 mM K2EGTA, 2.77 mM CaK2EGTA, 20 mM imidazole, 0.5 mM DTT, 20 mM taurine, 5.7 mM ATP, 14.3 mM PCr, 6.56 mM MES, with 100 µL of 0.5 M EGTA; pH 7.1) on top of...
When the vitreous ultrafiltrate was added to the PBE 94 column, one large and one small 280 nm-absorbing peak was removed by the starting buffer, 0.025M imidazole-HC1, ph 7.4. THe initial, larger peak had a slight inhibitory activity, while the second peak had no inhibitory activity. The...
Finally the A-substituent may be of a wholly different character, such as in the case of the methoxy- or p-ethoxybenzimidazole, or in the case of the /-mercaptoor /-thioalkylbenzimidazole or naphthimidazole. Among these products those are inter alia valuable in which the p-substituent ...
pH's, NaCl content, Diethylamine of various molarities, pH's, NaCl content, Imidazole of various molarities, pH's, NaCl content, Tricine of various molarities, pH's, NaCl content, Triethanolamine of various molarities, pH's, NaCl content, Tris of various molarities, pH's, NaCl content....