Dopamine beta-hydroxylase (DBH) enzyme activity was associated in rat superior cervical ganglion with tetrameric DBH-A (294,000 D) and dimeric DBH-B (147,000 D) and in rat adrenal gland with DBH-A and a novel molecular form of DBH, defined as DBH-C, with a molecular weight of 125,...
Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons CYTOCHROME-C-OXIDASEDNA GENE-EXPRESSIONSTEM-CELLSMitochondrial dysfunction is implicated in the pathophysiology of Parkinson's disease (PD), a common age-... M Ekstrand,M Terzioglu,D Galter,... - 《Proceedings of the...
Drug discovery is an expensive process in both time and cost with a daunting attrition rate. As revealed by a recent study1, the average cost of developing a new drug was ~1 billion dollars and has been ever increasing2. In the past decade, the practice of drug discovery has been undergo...
Khan Z. U., Gutierrez A., Martin R., Penafiel A., Rivera A., and De La Calle A. (1998) Differential regional and cellular distribution of dopamine D2-like receptors: an immunocytochemical study of subtype-specific antibodies in rat and human brain.J. Comp. Neurol.402, 353–371. Artic...
Serotonin, dopamine and GABA involvement in alcohol drinking of selectively bred rats lines of rats selectively bred for their high alcohol-seeking behavior, namely the alcohol-preferring P line and the high alcohol-drinking HAD line of ... WJ Mcbride,JM Murphy,L Lumeng,... - 《Alcohol》 被...
A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. et al . (1997) A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Human Molecular ... A Tadao,M Gao,H Hideo,.....
Activity-based anorexia (ABA), which refers to the weight loss, hypophagia, and hyperactivity exhibited by rodents exposed to both running wheels and scheduled fasting, provides a model for aspects of AN. Increased dopamine D2/D3 receptor binding in the anteroventral striatum has been reported ...
of dopamine D-2 receptors differ in their structure, G-protein-coupled and effector. Each of the three basic receptor units shows a certain degree of heterogeneity, which may affect the quality and the kinetic of the response. This variety may represent the molecular basis for the diversity in...
Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic ser... Structure-affinity investigations concerning the substituents in the indole nucleus and the 2-imidazolidinone ring system in the 2-(methylamino)...
AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors. Nat Neurosci 2012; 15: 1108–1110. Article CAS PubMed PubMed Central Google Scholar Palmiter RD . New game for hunger neurons. Nat Neurosci 2012; 15: 1060–1061. Article CAS PubMed Google ...