First of all, while the human Rho kinases contain a threonine in their activation loop at the position corresponding to that phosphorylated in many serine/threonine kinases of the AGC family, arthropod Rho kinases encode an asparagine. Furthermore, Rho kinases belong to a subfamily of the AGC ...
In all such cases reproted in the literature, a molecular weight value is used (16950.5 and 17199, respectively) which is based on the assumption that amino acid 122 in this 153 amino-acid-long protein is asparagine, overlooking a published suggestion that it is aspartic acid instead. Since ...
A protease responsible for post-translational cleavage of a conserved Asn-Gly linkage in glycinin, the major seed storage protein of soybean The assembly of 11S globulin seed storage proteins in plants is regulated in part by the activity of a protease that cleaves between asparagine and glycine....
Botulinum C3 ADP-ribosyltransferase, a 23-KDa exoenzyme secreted from certain strains of types C and D Clostridium botulinum, specifically ADP-ribosylates the rho family of these GTP-binding proteins. This ADP-ribosylation occurs at a specific asparagine residue in their putative effector domain, and...
(IC3). The approximate size of each structural domain is indicated (Fig.1a, see the corresponding legend for more details) [22]. Eight asparagine residues in consensus N-glycosylation sites (Asn-X-Ser/Thr-X sequons, where X is any amino acid except proline) are found in human and ...
Vascular complications of diabetes pose a severe threat to human health. Prevention and treatment protocols based on a single vascular complication are no longer suitable for the long-term management of patients with diabetes. Diabetic panvascular diseas
This chapter highlights recent developments in the analysis of proteins glycosylated of the amino groups ( N ) of asparagine residues (i.e., N -glycans) by... M Nakano,K Kakehi,N Taniguchi,... - Humana Press 被引量: 7发表: 2011年 Molecular weight diversity among murine class I antigen...
Mouse primary stromal cells were cultured in RPMI-1640 Medium (Invitrogen) with 50 μM 2-mercaptoethanol, 100 μM asparagine and 2 mM glutamine. All full media were supplemented with 10% fetal bovine serum (FBS) (Gibco) and 1% penicillin-streptomycin (P/S) (Invitrogen). Mice FSP1-...
Predicting interactions between proteins and other biomolecules solely based on structure remains a challenge in biology. A high-level representation of protein structure, the molecular surface, displays patterns of chemical and geometric features that f
Fig.1a) to the newly exposed carboxyl terminus of the so-called ω-residue (Fig.1a)1,2,20. The ω-site is not a specific residue but rather has a small site chain such as glycine, alanine, serine, cysteine, aspartate, and asparagine. The CSP also lacks sequence consensus but rather ...