Understanding stabilizing and destabilizing interactions between protein drugs and formulation excipients provide fundamental mechanisms for ensuring the stability and quality of biological products. This article reviews the molecular studies of biologics using solution and solid-state NMR spectroscopy on ...
Research ArticleUnderstanding the Critical Role of Glycolysis-Related lncRNAs inLung Adenocarcinoma Based on Three Molecular SubtypesPeng Cao , 1 Bo Zhao, 1 Yajie Xiao, 2 Shan Hu, 1 Kangle Kong, 1 Peng Han, 1 Jiaqi Yue, 1Yu Deng, 1 Zhikun Zhao, 2 Dongfang Wu , 2 Lu Zhang , 3 and ...
Predicated on substantial gains in our understanding of the natural history and molecular biology of bladder cancer, recent years have seen an explosion of new applied technologies to aid clinicians in the management of bladder cancer. Herein we present a systematic overview of general conceptual ...
Looking forward, we propose that fundamental understanding of the molecular origin of OPV stability is a key research theme for next-generation OPVs. Additionally, we discuss the tools required, across length scales, to implement these design rules, particularly the use of in situ Raman ...
Circular logic: understanding RNA’s strangest form yet Circular RNAs are prevalent, mysterious and fascinating, but their study requires great care. Amber Dance Article 06 November 2024|Open Access Identification and genetic dissection of convergent persister cell states ...
Toxicology has made steady advances over the last 60+ years in understanding the mechanisms of toxicity at an increasingly finer level of cellular organization. Traditionally, toxicological studies have used animal models. However, the general adoption of the principles of 3R (Replace, Reduce, Refine...
Only through a deeper understanding of the influence of physical exercise on the growth and development of malignancy, metabolic pathways, and systemic immune functions can we fully understand the correlation between exercise and cancer prevention and treatment and, thus, make personalized exercise ...
Evidence of connections between microbial activity and the Earth's biogeochemical cycles is all around us, and motivates our interest in the mechanisms of microbial transformations, their rates, and the distribution of microbial activities across environment types and over Earth history. In general, the...
Polymer binders in battery electrodes may be either active or passive. This distinction depends on whether the polymer influences charge or mass transport in the electrode. Although it is desirable to understand how to tailor the macromolecular design of
E. The redox environment in the mitochondrial intermembrane space is maintained separately from the cytosol and matrix. J. Biol. Chem. 283, 29126–29134 (2008). CAS PubMed PubMed Central Google Scholar Viña, J. & Borrás, C. Women live longer than men: understanding molecular mechanisms...