Ruslan NovosiadlyMichael KalosMolecular Therapy - OncolyticsNovosiadly R, Kalos M. High-content molecular profiling of T-cell therapy in oncology. Mol Ther Oncolytics (2016) 3:16009. doi:10.1038/mto.2016.9
further enhances the effectiveness of this approach to eradicate cancer. with a particular emphasis on cik cell therapy, which recently completed 30 years, we highlight the role of the pd-1/pd-l1 axis in nsclc and sclc. besides, we provide insights into the potential synergies of pd-1/pd-...
CTC profiling is an essential aspect of liquid biopsy; nevertheless, its importance in cancer diagnosis is not as high as its role in recurrence, therapeutic response, or oncology research [85]. Very few CTCs are found in the bloodstream, and their quantity is proportional to the tumor size. ...
Cell-specific metabolic reprogramming of tumors for bioactivatable ferroptosis therapy. ACS Nano 16, 3965–3984 (2022). Article CAS PubMed Google Scholar Ohta, K., Saka, N. & Nishio, M. Human parainfluenza virus type 2 V protein modulates iron homeostasis. J. Virol. https://doi.org/...
Significant advances in anticancer therapy have been made in recent decades. Of the various therapeutic agents, chemotherapy has become a preferred choice for most managements of cancers due to its high cytotoxicity of chemo agents against cancer cells [2]. However, these conventional small-molecular...
NeuroOncology 2003, 5, 79–88. 73. Westphal, M.; Yia-Herttuala, S.; Martin, J. Adenovirus-mediated gene therapy with sitimagene ceradenovec followed by intravenous ganciclovir for patients with operable high-grade glioma (ASPECT): A randomized, open-label, phase 3 tr...
[27]. these experiments provide the insight that emt has a versatile function in tumorigenesis and it is not limited to metastasis, while it can affect therapy response and impair the immune system. circrnas: an overview in oncology more than four decades ago, a new kind of rna molecule ...
(ncRNAs), along with their modifiers, have been investigated to play key roles in regulating tumor development and mediating therapy resistance within various cancers, such as hepatocellular carcinoma, breast cancer, lung cancer, gastric cancer, etc. In this review, we attempt to elucidate the ...
Targeting ROS as anti-cancer therapy Even though cancer cells exhibit an enhanced antioxidant system, they still maintain higher ROS levels than normal cells [20, 109]. ROS load increases with the tumor progression [23]. Compared to normal cells, cancer cells are closer to the threshold of ROS...
tumor antigens to activate antitumor immunity, indicating a potential target for immunotherapy. For instance, miR-138 could target CTLA-4 and PD-1 to escape from immune checkpoint therapy in glioma [128], hence,circ_002136 may also has a potential immunotherapy target through sponging miR138 [...